MeSH Browser

MeSH Heading: N-Formylmethionine Leucyl-Phenylalanine
Tree Number(s): D02.886.030.676.450.440; D12.125.072.050.685.445; D12.125.142.666.500; D12.125.166.676.450.440; D12.644.456.400; D23.125.685
Unique ID: D009240
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009240
Scope Note: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.
Entry Version: FMLP
Entry Term(s): F-Met-Leu-Phe; Formylmet-Leu-Phe; Formylmethionyl Peptide; Formylmethionyl-Leucyl-Phenylalanine; Formylmethionylleucylphenylalanine; N-Formyl-Methionyl-Leucyl-Phenylalanine; N-Formylated Peptide; N-formylmethionyl-leucyl-phenylalanine; fMet-Leu-Phe
CAS Type 1 Name: L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-
Previous Indexing: Chemotactic Factors (1980-1983); Chemotaxis (1970-1979); Chemotaxis, Leukocyte (1977-1983); Cytology (1966-1969); Methionine (1966-1974); N-Formylmethionine (1975-1983); Oligopeptides (1973-1983); Peptides (1966-1972)
Public MeSH Note: 85; was N-FORMYL-METHIONYL-LEUCYL-PHENYLALANINE 1984; CHEMOTACTIC PEPTIDE was see N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE 1984-90
Online Note: use N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE to search N-FORMYL-METHIONYL-LEUCYL-PHENYLALANINE 1984
History Note: 85; was N-FORMYL-METHIONYL-LEUCYL-PHENYLALANINE 1984; CHEMOTACTIC PEPTIDE was see N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE 1984-90
Date Established: 1984/01/01
Date of Entry: 1983/06/13
Revision Date: 2015/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Sulfur Compounds [D02.886]
  - Amino Acids, Sulfur [D02.886.030]
    - Methionine [D02.886.030.676]
      - N-Formylmethionine [D02.886.030.676.450]
        
        N-Formylmethionine Leucyl-Phenylalanine [D02.886.030.676.450.440]

Amino Acids, Peptides, and Proteins [D12]
- Amino Acids [D12.125]
  - Amino Acids, Cyclic [D12.125.072]
    - Amino Acids, Aromatic [D12.125.072.050]
      - Phenylalanine [D12.125.072.050.685]
        
        Dihydroxyphenylalanine [D12.125.072.050.685.400]
        
        Fenclonine [D12.125.072.050.685.440]
        
        N-Formylmethionine Leucyl-Phenylalanine [D12.125.072.050.685.445]
        
        Nateglinide [D12.125.072.050.685.448]
        
        p-Fluorophenylalanine [D12.125.072.050.685.450]
        
        Melphalan [D12.125.072.050.685.500]

Amino Acids, Peptides, and Proteins [D12]
- Amino Acids [D12.125]
  - Amino Acids, Essential [D12.125.142]
    - Phenylalanine [D12.125.142.666]
      - N-Formylmethionine Leucyl-Phenylalanine [D12.125.142.666.500]

Amino Acids, Peptides, and Proteins [D12]
- Amino Acids [D12.125]
  - Amino Acids, Sulfur [D12.125.166]
    - Methionine [D12.125.166.676]
      - N-Formylmethionine [D12.125.166.676.450]
        
        N-Formylmethionine Leucyl-Phenylalanine [D12.125.166.676.450.440]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Oligopeptides [D12.644.456]

Biological Factors [D23]
- Chemotactic Factors [D23.125]

N-Formylmethionine Leucyl-Phenylalanine Preferred

Concept UI: M0014396
Scope Note: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.
Terms: N-Formylmethionine Leucyl-Phenylalanine Preferred Term
Term UI T027545
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1984); Formylmet-Leu-Phe
Term UI T027546
Date06/13/1983
LexicalTag NON
ThesaurusID UNK (19XX); Formylmethionylleucylphenylalanine
Term UI T027547
Date06/13/1983
LexicalTag NON
ThesaurusID UNK (19XX); N-Formyl-Methionyl-Leucyl-Phenylalanine
Term UI T027549
Date06/08/1984
LexicalTag NON
ThesaurusID UNK (19XX); Formylmethionyl-Leucyl-Phenylalanine
Term UI T027550
Date09/20/1983
LexicalTag NON
ThesaurusID UNK (19XX)

Formylmethionyl Peptide Narrower

N-formylmethionyl-leucyl-phenylalanine Narrower

F-Met-Leu-Phe Narrower

N-Formylmethionine Leucyl-Phenylalanine MeSH Descriptor Data 2025