MeSH Browser

MeSH Heading: Fenclonine
Tree Number(s): D12.125.072.050.685.440
Unique ID: D010134
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D010134
Scope Note: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Entry Term(s): CP-10,188; DL-3-(4-Chlorophenyl)alanine; Fenclonin; Fenclonine (L)-Isomer; Fenclonine Hydrobromide; Fenclonine Hydrochloride; Fenclonine, (D)-Isomer; p-Chlorophenylalanine; para-Chlorophenylalanine
Pharm Action: Enzyme Inhibitors
Serotonin Antagonists
Registry Number: R5J7E3L9SP
Related Numbers: 14091-08-8; 14173-39-8; 1991-78-2; 23633-07-0; 51274-82-9; 55327-86-1; 7424-00-2
CAS Type 1 Name: DL-Phenylalanine, 4-chloro-
Previous Indexing: Phenylalanine (1966-1970)
Public MeSH Note: 93; see P-CHLOROPHENYLALANINE 1973-92; for FENCLONINE see P-CHLOROPHENYLALANINE 1978-92
History Note: 93(71)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0015725
Registry Number: R5J7E3L9SP
Related Numbers: 14091-08-8; 14173-39-8; 1991-78-2; 23633-07-0; 51274-82-9; 55327-86-1; 7424-00-2
Scope Note: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Terms: Fenclonine Preferred Term
Term UI T030002
Date01/01/1999
LexicalTag NON
ThesaurusID; para-Chlorophenylalanine
Term UI T030003
Date05/15/1976
LexicalTag NON
ThesaurusID UNK (19XX); p-Chlorophenylalanine
Term UI T030005
Date03/09/1992
LexicalTag NON
ThesaurusID NLM (1993); DL-3-(4-Chlorophenyl)alanine
Term UI T030004
Date03/31/1994
LexicalTag NON
ThesaurusID NLM (1995); Fenclonin
Term UI T030006
Date04/22/1977
LexicalTag NON
ThesaurusID UNK (19XX)

Fenclonine MeSH Descriptor Data 2023