MeSH Browser

MeSH Heading: Glutamate Decarboxylase
Tree Number(s): D08.811.520.224.125.250
Unique ID: D005968
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005968
Scope Note: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
Entry Term(s): Glutamate Carboxy-Lyase; Glutamic Acid Decarboxylase
Registry Numbers: EC 4.1.1.15
CAS Type 1 Name: L-Glutamate-1-carboxy-lyase
Previous Indexing: Carboxy-Lyases (1973-1974); Glutamates (1973-1974)
Public MeSH Note: 84; was see under CARBOXY-LYASES 1975-83
History Note: 84(75); was see under CARBOXY-LYASES 1975-83
Date Established: 1984/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0009373
Registry Numbers: EC 4.1.1.15
Scope Note: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
Terms: Glutamate Decarboxylase Preferred Term
Term UI T018085
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Glutamate Carboxy-Lyase
Term UI T018084
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Glutamic Acid Decarboxylase
Term UI T018086
Date10/14/1983
LexicalTag NON
ThesaurusID UNK (19XX)

Glutamate Decarboxylase MeSH Descriptor Data 2025