MeSH Browser

MeSH Heading: Pyruvate Decarboxylase
Tree Number(s): D08.811.520.224.125.750
Unique ID: D011767
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011767
Scope Note: Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
Entry Term(s): 2-Oxo Acid Carboxy-Lyase; Pyruvic Decarboxylase; alpha-Carboxylase; alpha-Ketoacid Carboxylase
Registry Numbers: EC 4.1.1.1
Related Numbers: 9001-04-1
Previous Indexing: Carboxy-Lyases (1973-1974); Pyruvates (1973-1974)
Public MeSH Note: 91; was see under CARBOXY-LYASES 1975-90
History Note: 91(75); was see under CARBOXY-LYASES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0018289
Registry Numbers: EC 4.1.1.1
Related Numbers: 9001-04-1
Scope Note: Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
Terms: Pyruvate Decarboxylase Preferred Term
Term UI T034781
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); 2-Oxo Acid Carboxy-Lyase
Term UI T034778
Date05/17/1976
LexicalTag NON
ThesaurusID UNK (19XX); alpha-Carboxylase
Term UI T034779
Date05/17/1976
LexicalTag NON
ThesaurusID UNK (19XX); alpha-Ketoacid Carboxylase
Term UI T034780
Date05/17/1976
LexicalTag NON
ThesaurusID UNK (19XX); Pyruvic Decarboxylase
Term UI T034782
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Pyruvate Decarboxylase MeSH Descriptor Data 2025