MeSH Browser

MeSH Heading: Bisbenzimidazole
Tree Number(s): D03.633.100.103.145
Unique ID: D006690
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006690
Scope Note: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Entry Term(s): (S,S)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethanediol; 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride; A 36683; A 36683, (R-(R*,R*))-isomer; A 36683, (R-(R*,S*))-isomer; A 36683, (S-(R*,R*))-isomer; A 36683, dihydrochloride, (S-(R*,R*))-isomer; A 37536; A-36683; Abbot 36683; Bis-Benzimidazole; Bisbenzimidazole Trihydrochloride; Bisbenzimide; Hoe-33258; Hoechst 33258; NSC-322921; Pibenzimol
Pharm Action: Filaricides
Fluorescent Dyes
Registry Numbers: LHQ7J5KV9B; 0; 34435-09-1; 34435-11-5; 23491-45-4; 34435-13-7; 34435-12-6
Related Numbers: 23491-44-3; 34435-09-1; 34435-11-5; 34435-12-6; 34435-13-7
CAS Type 1 Name: 4-(5-(5-(4-Methylpiperazin-1-yl)benzimidazol-2- yl)benzimidazol-2-yl)phenol
Previous Indexing: Benzimidazoles (1971-1976); Phenols (1972-1975); Piperazines (1971-1975)
Public MeSH Note: 2008; see BISBENZIMIDE 1991-2008, see BENZIMIDAZOLES 1977-1990
History Note: 2008(1977)
Date Introduced: 1991/01/01
Last Updated: 2027/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0515726
Registry Numbers: LHQ7J5KV9B
Related Numbers: 23491-44-3; 34435-09-1; 34435-11-5; 34435-12-6; 34435-13-7
Scope Note: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Terms: Bisbenzimidazole Preferred Term
Term UI T709723
Date11/19/2007
LexicalTag NON
ThesaurusID; (S,S)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethanediol
Term UI T084643
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (1975); Pibenzimol
Term UI T020232
Date10/01/1986
LexicalTag NON
ThesaurusID; Bis-Benzimidazole
Term UI T001151983
Date03/19/2026
LexicalTag NON
ThesaurusID NLM (2027)

Bisbenzimidazole MeSH Descriptor Data 2027