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Hypoxanthine Phosphoribosyltransferase MeSH Descriptor Data 2023


MeSH Heading
Hypoxanthine Phosphoribosyltransferase
Tree Number(s)
D08.811.913.400.725.450
Unique ID
D007041
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007041
Annotation
/defic: consider also LESCH-NYHAN SYNDROME or GOUT
Scope Note
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Entry Term(s)
Guanine Phosphoribosyltransferase
HGPRT
HPRT
HPRTase
Hypoxanthine-Guanine Phosphoribosyltransferase
IMP Pyrophosphorylase
Registry Number
EC 2.4.2.8
Related Numbers
9016-12-0
CAS Type 1 Name
IMP:pyrophosphate phospho-D-ribosyltransferase
Previous Indexing
Pentosephosphates (1972-1974)
Pentosyltransferases (1972-1974)
See Also
Gout
Lesch-Nyhan Syndrome
Public MeSH Note
75; GUANINE PHOSPHORIBOSYLTRANSFERASE was indexed under PENTOSYLTRANSFERASES 1978-91
Online Note
use HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (NM) to search GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1980-91
History Note
75; GUANINE PHOSPHORIBOSYLTRANSFERASE was GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1978-91
Date Established
1975/09/01
Date of Entry
1974/11/11
Revision Date
2019/05/24
Hypoxanthine Phosphoribosyltransferase Preferred
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