MeSH Browser

MeSH Heading: Mercaptopurine
Tree Number(s): D02.886.489.534; D03.633.100.759.570
Unique ID: D015122
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015122
Scope Note: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Entry Term(s): 1,7-Dihydro-6H-purine-6-thione; 6-Mercaptopurine; 6-Mercaptopurine Monohydrate; 6-Thiohypoxanthine; 6-Thiopurine; 6H-Purine-6-thione, 1,7-dihydro-; BW 57-323H; Leupurin; Mecaptopurine Anhydrous; Mercaptopurina Wellcome; Puri-Nethol; Purimethol; Purinethol
Pharm Action: Antimetabolites
Antimetabolites, Antineoplastic
Immunosuppressive Agents
Nucleic Acid Synthesis Inhibitors
Related Numbers: 50-44-2; 6112-76-1; PKK6MUZ20G
Public MeSH Note: 2018; see 6-Mecaptopurine 1985-2017; see MERCAPTOPURINE 1963-1984; see ARABINOSYL-6-MERCAPTOPURINE 1975-1991; MERCAPTOPURINE was indexed under 6-MERCAPTOPURINE 1975-1990
History Note: 2018(1985)
Date Established: 1985/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0023263
Related Numbers: 50-44-2; 6112-76-1; PKK6MUZ20G
Scope Note: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Terms: Mercaptopurine Preferred Term
Term UI T044187
Date04/16/1984
LexicalTag NON
ThesaurusID; 6-Mercaptopurine
Term UI T044182
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); 6H-Purine-6-thione, 1,7-dihydro-
Term UI T000942249
Date04/19/2018
LexicalTag NON
ThesaurusID NLM (2019); 6-Thiohypoxanthine
Term UI T044183
Date10/14/1983
LexicalTag NON
ThesaurusID UNK (19XX); 6-Thiopurine
Term UI T044184
Date10/26/1981
LexicalTag NON
ThesaurusID UNK (19XX); 1,7-Dihydro-6H-purine-6-thione
Term UI T044190
Date02/16/1996
LexicalTag NON
ThesaurusID NLM (1997); 6-Mercaptopurine Monohydrate
Term UI T359701
Date09/13/1999
LexicalTag NON
ThesaurusID

Mercaptopurine MeSH Descriptor Data 2025