MeSH Browser

MeSH Heading: Lymphocyte Culture Test, Mixed
Tree Number(s): E01.370.225.812.385.475; E05.200.812.385.475; E05.478.594.385.429
Unique ID: D007959
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007959
Annotation: NIM
Scope Note: Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
Entry Term(s): Leukocyte Culture Test, Mixed; Mixed Leukocyte Culture Test; Mixed Leukocyte Reaction; Mixed Lymphocyte Culture Test; Mixed Lymphocyte Reaction
Previous Indexing: Histocompatibility Testing (1968-1972); Leukocytes (1966-1972)
Public MeSH Note: 93; was LEUKOCYTE CULTURE TEST, MIXED 1973-92; LYMPHOCYTE CULTURE TEST, MIXED was see LEUKOCYTE CULTURE TEST, MIXED 1981-92
Online Note: use LYMPHOCYTE CULTURE TEST, MIXED to search LEUKOCYTE CULTURE TEST, MIXED 1973-92
History Note: 93; was LEUKOCYTE CULTURE TEST, MIXED 1973-92; LYMPHOCYTE CULTURE TEST, MIXED was see LEUKOCYTE CULTURE TEST, MIXED 1981-92
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2011/06/24

Allowable Qualifiers: adverse effects (AE)

classification (CL)

economics (EC)

ethics (ES)

history (HI)

instrumentation (IS)

methods (MT)

mortality (MO)

standards (ST)

statistics & numerical data (SN)

trends (TD)

veterinary (VE)

Diagnosis [E01]
- Diagnostic Techniques and Procedures [E01.370]
  - Clinical Laboratory Techniques [E01.370.225]
    - Immunologic Tests [E01.370.225.812]
      - Histocompatibility Testing [E01.370.225.812.385]
        
        Blood Grouping and Crossmatching [E01.370.225.812.385.120]
        
        Lymphocyte Culture Test, Mixed [E01.370.225.812.385.475]

Investigative Techniques [E05]
- Clinical Laboratory Techniques [E05.200]
  - Immunologic Tests [E05.200.812]
    - Histocompatibility Testing [E05.200.812.385]
      - Blood Grouping and Crossmatching [E05.200.812.385.120]
      - Lymphocyte Culture Test, Mixed [E05.200.812.385.475]

Investigative Techniques [E05]
- Immunologic Techniques [E05.478]
  - Immunologic Tests [E05.478.594]
    - Histocompatibility Testing [E05.478.594.385]
      - Blood Grouping and Crossmatching [E05.478.594.385.120]
      - Lymphocyte Culture Test, Mixed [E05.478.594.385.429]

Lymphocyte Culture Test, Mixed Preferred

Concept UI: M0012408
Scope Note: Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
Terms: Lymphocyte Culture Test, Mixed Preferred Term
Term UI T023728
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1973); Mixed Leukocyte Culture Test
Term UI T023725
Date09/16/1991
LexicalTag NON
ThesaurusID NLM (1993); Leukocyte Culture Test, Mixed
Term UI T023726
Date09/16/1991
LexicalTag NON
ThesaurusID NLM (1993); Mixed Lymphocyte Culture Test
Term UI T023727
Date09/16/1991
LexicalTag NON
ThesaurusID NLM (1993); Mixed Leukocyte Reaction
Term UI T023729
Date09/16/1991
LexicalTag NON
ThesaurusID NLM (1993); Mixed Lymphocyte Reaction
Term UI T023730
Date09/16/1991
LexicalTag NON
ThesaurusID NLM (1993)

Lymphocyte Culture Test, Mixed MeSH Descriptor Data 2025