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Nomifensine MeSH Descriptor Data 2023


MeSH Heading
Nomifensine
Tree Number(s)
D03.633.100.531.535
Unique ID
D009627
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D009627
Scope Note
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Entry Term(s)
Hoe-984
Linamiphen
Merital
Nomifensin
Nomifensine Maleate
Nomifensine Maleate (1:1)
Pharm Action
Dopamine Uptake Inhibitors
Registry Number
1LGS5JRP31
Related Numbers
24526-64-5
32795-47-4
76S8CUH5MR
CAS Type 1 Name
8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
Previous Indexing
Isoquinolines (1969-1977)
Quinolines (1966-1968)
Public MeSH Note
86; was see under ISOQUINOLINES 1978-85
History Note
86(78); was see under ISOQUINOLINES 1978-85
Date Established
1986/01/01
Date of Entry
1977/04/22
Revision Date
2016/05/31
Nomifensine Preferred
Nomifensine Maleate Narrower
Hoe-984 Narrower
Merital Narrower
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