MeSH Browser

MeSH Heading: Palonosetron
Tree Number(s): D03.605.687.319; D03.633.100.531.629
Unique ID: D000077924
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077924
Scope Note: Isoquinoline and quinuclidine derivative that acts as a 5-HT3 RECEPTOR antagonist. It is used in the prevention of nausea and vomiting induced by cytotoxic chemotherapy, and for the prevention of post-operative nausea and vomiting.
Entry Term(s): 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one; 2-QHBIQO; Aloxi; Palonosetron Hydrochloride; Palonosetron, (3R)-; Palonosetron, (R-(R*,R*))-isomer; Palonosetron, (R-(R*,S*))-isomer; Palonosetron, (S-(R*,S*))-isomer; RS 25233-197; RS 25233-198; RS 25259; RS 25259-197; RS 25259-198; RS-25233-197; RS-25233-198; RS-25259; RS-25259-197; RS-25259-198
Pharm Action: Antiemetics
Serotonin 5-HT3 Receptor Antagonists
Registry Numbers: 5D06587D6R; 0; 135729-73-6; 2UCB21ER4V; 149654-00-2; 23310D4I19
Related Numbers: 135729-61-2; 135729-73-6; 149653-99-6; 149654-00-2; 23310D4I19; 2UCB21ER4V
CAS Type 1 Name: 1H-Benz(de)isoquinolin-1-one, 2-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-, (3aS)-
Public MeSH Note: 2019; PALONOSETRON was indexed under ISOQUINOLINES and QUINUCLIDINES 1993-2018
History Note: 2019 (1993)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Palonosetron MeSH Descriptor Data 2025