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Nonsuppressible Insulin-Like Activity MeSH Descriptor Data 2023


MeSH Heading
Nonsuppressible Insulin-Like Activity
Tree Number(s)
D12.776.124.862.575
Unique ID
D009632
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D009632
Annotation
note category; a blood protein mimicking blood insulin
Scope Note
A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.
Entry Term(s)
NSILA
NSILA-P
NSILA-S
Nonsuppressible Insulinlike Activity
Registry Number
0
Previous Indexing
Blood Proteins (1966-1976)
Insulin (1966-1976)
Public MeSH Note
77
History Note
77
Date Established
1977/01/01
Date of Entry
1976/05/19
Revision Date
2006/07/05
Nonsuppressible Insulin-Like Activity Preferred
NSILA-P Narrower
NSILA-S Narrower
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