MeSH Browser

MeSH Heading: Nonsuppressible Insulin-Like Activity
Tree Number(s): D12.776.124.862.575
Unique ID: D009632
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009632
Annotation: note category; a blood protein mimicking blood insulin
Scope Note: A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.
Entry Term(s): NSILA; NSILA-P; NSILA-S; Nonsuppressible Insulinlike Activity
Registry Numbers: 0
Previous Indexing: Blood Proteins (1966-1976); Insulin (1966-1976)
Public MeSH Note: 77
History Note: 77
Date Established: 1977/01/01
Date of Entry: 1976/05/19
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0014953
Registry Numbers: 0
Scope Note: A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.
Terms: Nonsuppressible Insulin-Like Activity Preferred Term
Term UI T028653
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); NSILA
Term UI T028654
Date05/12/1976
LexicalTag ABB
ThesaurusID UNK (19XX); Nonsuppressible Insulinlike Activity
Term UI T028655
Date12/07/1977
LexicalTag NON
ThesaurusID UNK (19XX)

Nonsuppressible Insulin-Like Activity MeSH Descriptor Data 2025