MeSH Browser

MeSH Heading: Stevens-Johnson Syndrome
Tree Number(s): C07.465.864.500; C17.800.174.600.900; C17.800.229.400.683; C17.800.865.475.683; C20.543.418.787; C25.100.468.380.900
Unique ID: D013262
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013262
Scope Note: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Entry Term(s): Drug-Induced Stevens Johnson Syndrome; Drug-Induced Stevens-Johnson Syndrome; Epidermal Necrolysis, Toxic; Lyell's Syndrome; Mycoplasma-Induced Stevens Johnson Syndrome; Mycoplasma-Induced Stevens-Johnson Syndrome; Nonstaphylococcal Scalded Skin Syndrome; Scalded Skin Syndrome, Nonstaphylococcal; Stevens Johnson Syndrome Toxic Epidermal Necrolysis; Stevens Johnson Syndrome Toxic Epidermal Necrolysis Spectrum; Stevens-Johnson Syndrome Toxic Epidermal Necrolysis; Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum; Toxic Epidermal Necrolysis; Toxic Epidermal Necrolysis Stevens Johnson Syndrome; Toxic Epidermal Necrolysis Stevens Johnson Syndrome Spectrum; Toxic Epidermal Necrolysis Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis Stevens-Johnson Syndrome Spectrum
NLM Classification #: WR 150
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2022/07/11

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Stomatognathic Diseases [C07]
- Mouth Diseases [C07.465]
  - Stomatitis [C07.465.864]

Skin and Connective Tissue Diseases [C17]
- Skin Diseases [C17.800]
  - Dermatitis [C17.800.174]
    - Drug Eruptions [C17.800.174.600]

Skin and Connective Tissue Diseases [C17]
- Skin Diseases [C17.800]
  - Erythema [C17.800.229]
    - Erythema Multiforme [C17.800.229.400]
      - Stevens-Johnson Syndrome [C17.800.229.400.683]

Skin and Connective Tissue Diseases [C17]
- Skin Diseases [C17.800]
  - Skin Diseases, Vesiculobullous [C17.800.865]
    - Erythema Multiforme [C17.800.865.475]
      - Stevens-Johnson Syndrome [C17.800.865.475.683]

Immune System Diseases [C20]
- Hypersensitivity [C20.543]
  - Hypersensitivity, Delayed [C20.543.418]

Chemically-Induced Disorders [C25]
- Drug-Related Side Effects and Adverse Reactions [C25.100]
  - Drug Hypersensitivity [C25.100.468]
    - Drug Eruptions [C25.100.468.380]

Stevens-Johnson Syndrome Preferred

Epidermal Necrolysis, Toxic Related

Concept UI: M0007553
Scope Note: An exfoliative disease of skin seen primarily in adults and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure.
Terms: Epidermal Necrolysis, Toxic Preferred Term
Term UI T014690
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1964); Toxic Epidermal Necrolysis
Term UI T014689
Date06/17/1991
LexicalTag NON
ThesaurusID; Lyell's Syndrome
Term UI T014691
Date03/30/1974
LexicalTag NON
ThesaurusID; Nonstaphylococcal Scalded Skin Syndrome
Term UI T014692
Date04/02/1992
LexicalTag NON
ThesaurusID NLM (1993); Scalded Skin Syndrome, Nonstaphylococcal
Term UI T014693
Date04/02/1992
LexicalTag NON
ThesaurusID NLM (1993)

Drug-Induced Stevens Johnson Syndrome Narrower

Mycoplasma-Induced Stevens-Johnson Syndrome Narrower

Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Broader

Stevens-Johnson Syndrome MeSH Descriptor Data 2025