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Thalidomide MeSH Descriptor Data 2021


MeSH Heading
Thalidomide
Tree Number(s)
D02.241.223.805.810.800
D03.383.621.808.800
D03.633.100.513.750.750
Unique ID
D013792
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013792
Scope Note
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Entry Term(s)
Sedoval
Thalomid
Pharm Action
Immunosuppressive Agents
Leprostatic Agents
Teratogens
Angiogenesis Inhibitors
Registry Number
4Z8R6ORS6L
Related Numbers
50-35-1
CAS Type 1 Name
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2017/05/24
Thalidomide Preferred
Sedoval Narrower
Thalomid Narrower
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