MeSH Browser

MeSH Heading: Thiorphan
Tree Number(s): D02.886.030.893; D12.125.166.893; D12.125.481.700.750
Unique ID: D015244
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015244
Scope Note: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Entry Term(s): (3-Mercapto-2-benzylpropionyl)glycine; Thiorphan, (R)-Isomer; Thiorphan, (S)-Isomer; Tiorphan
Pharm Action: Protease Inhibitors
Registry Numbers: B79L7B5X3Z; 95908-99-9; 95909-00-5
Related Numbers: 107672-11-7; 76721-89-6; 95908-99-9; 95909-00-5
CAS Type 1 Name: Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-
Previous Indexing: Mercaptopropionylglycine/analogs & derivatives (1980-1988)
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/05/16
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0023434
Registry Numbers: B79L7B5X3Z
Related Numbers: 107672-11-7; 76721-89-6; 95908-99-9; 95909-00-5
Scope Note: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Terms: Thiorphan Preferred Term
Term UI T044639
Date01/01/1999
LexicalTag NON
ThesaurusID; (3-Mercapto-2-benzylpropionyl)glycine
Term UI T044638
Date05/16/1988
LexicalTag NON
ThesaurusID UNK (19XX); Tiorphan
Term UI T044640
Date05/16/1988
LexicalTag NON
ThesaurusID UNK (19XX)

Thiorphan MeSH Descriptor Data 2025