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Thiorphan MeSH Descriptor Data 2022


MeSH Heading
Thiorphan
Tree Number(s)
D02.886.030.893
D12.125.166.893
D12.125.481.700.750
Unique ID
D015244
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015244
Scope Note
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Entry Term(s)
(3-Mercapto-2-benzylpropionyl)glycine
Thiorphan, (R)-Isomer
Thiorphan, (S)-Isomer
Tiorphan
Pharm Action
Protease Inhibitors
Registry Number
B79L7B5X3Z
Related Numbers
107672-11-7
76721-89-6
95908-99-9
95909-00-5
CAS Type 1 Name
Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-
Previous Indexing
Mercaptopropionylglycine/analogs & derivatives (1980-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/05/16
Revision Date
2013/07/08
Thiorphan Preferred
Thiorphan, (R)-Isomer Narrower
Thiorphan, (S)-Isomer Narrower
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