MeSH Browser

MeSH Heading: Oncogene Protein pp60(v-src)
Tree Number(s): D08.811.913.696.620.682.725.800.472; D12.776.476.568.800.472; D12.776.624.664.520.750.760; D12.776.964.700.750.760; D12.776.964.775.750.760
Unique ID: D015688
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015688
Scope Note: A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.
Entry Term(s): Avian Sarcoma Virus-Transforming Protein; Oncogene Protein pp60(src); Oncogene Protein src; Phosphoprotein pp60(v-src); Rous Sarcoma Virus-Transforming Protein pp60(v-src); p60(v-src); pp60 v-src; pp60(v-src); src Oncogene Product pp60; src Oncogene Protein pp60; v-src Protein; v-src Protein pp60
CAS Type 1 Name: Kinase (phosphorylating), protein pp60src
Previous Indexing: Retroviridae Proteins (1986-1989); Viral Proteins (1981-1985)
Public MeSH Note: 91; was ONCOGENE PROTEIN PP60(SRC) 1990; PP60(SRC) was see ONCOGENE PROTEIN PP60(SRC) 1990
Online Note: use ONCOGENE PROTEIN PP60(V-SRC) to search ONCOGENE PROTEIN PP60(SRC) & PP60(SRC) 1990
History Note: 91; was ONCOGENE PROTEIN PP60(SRC) 1990; PP60(SRC) was see ONCOGENE PROTEIN PP60(SRC) 1990
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        src-Family Kinases [D08.811.913.696.620.682.725.800]
        
        CSK Tyrosine-Protein Kinase [D08.811.913.696.620.682.725.800.158]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D08.811.913.696.620.682.725.800.315]
        
        Oncogene Protein pp60(v-src) [D08.811.913.696.620.682.725.800.472]
        
        Proto-Oncogene Proteins c-fyn [D08.811.913.696.620.682.725.800.551]
        
        Proto-Oncogene Proteins c-hck [D08.811.913.696.620.682.725.800.590]
        
        Proto-Oncogene Proteins c-yes [D08.811.913.696.620.682.725.800.610]
        
        Proto-Oncogene Proteins pp60(c-src) [D08.811.913.696.620.682.725.800.630]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - src-Family Kinases [D12.776.476.568.800]
        
        CSK Tyrosine-Protein Kinase [D12.776.476.568.800.158]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.476.568.800.315]
        
        Oncogene Protein pp60(v-src) [D12.776.476.568.800.472]
        
        Proto-Oncogene Proteins c-fyn [D12.776.476.568.800.551]
        
        Proto-Oncogene Proteins c-hck [D12.776.476.568.800.590]
        
        Proto-Oncogene Proteins c-yes [D12.776.476.568.800.610]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.476.568.800.630]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Oncogene Proteins, Viral [D12.776.624.664.520]
        
        Retroviridae Proteins, Oncogenic [D12.776.624.664.520.750]
        
        Fusion Proteins, gag-onc [D12.776.624.664.520.750.320]
        
        Gene Products, rex [D12.776.624.664.520.750.470]
        
        Gene Products, tax [D12.776.624.664.520.750.480]
        
        Oncogene Protein gp140(v-fms) [D12.776.624.664.520.750.650]
        
        Oncogene Protein p21(ras) [D12.776.624.664.520.750.710]
        
        Oncogene Protein p55(v-myc) [D12.776.624.664.520.750.750]
        
        Oncogene Protein pp60(v-src) [D12.776.624.664.520.750.760]
        
        Oncogene Protein v-akt [D12.776.624.664.520.750.788]
        
        Oncogene Protein v-cbl [D12.776.624.664.520.750.817]
        
        Oncogene Protein v-crk [D12.776.624.664.520.750.846]
        
        Oncogene Protein v-maf [D12.776.624.664.520.750.860]
        
        Oncogene Proteins v-abl [D12.776.624.664.520.750.875]
        
        Oncogene Proteins v-erbA [D12.776.624.664.520.750.882]
        
        Oncogene Proteins v-erbB [D12.776.624.664.520.750.883]
        
        Oncogene Proteins v-fos [D12.776.624.664.520.750.887]
        
        Oncogene Proteins v-mos [D12.776.624.664.520.750.900]
        
        Oncogene Proteins v-myb [D12.776.624.664.520.750.903]
        
        Oncogene Proteins v-raf [D12.776.624.664.520.750.920]
        
        Oncogene Proteins v-rel [D12.776.624.664.520.750.925]
        
        Oncogene Proteins v-sis [D12.776.624.664.520.750.935]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Oncogene Proteins, Viral [D12.776.964.700]
      - Retroviridae Proteins, Oncogenic [D12.776.964.700.750]
        
        Fusion Proteins, gag-onc [D12.776.964.700.750.320]
        
        Gene Products, rex [D12.776.964.700.750.470]
        
        Gene Products, tax [D12.776.964.700.750.480]
        
        Oncogene Protein gp140(v-fms) [D12.776.964.700.750.650]
        
        Oncogene Protein p21(ras) [D12.776.964.700.750.710]
        
        Oncogene Protein p55(v-myc) [D12.776.964.700.750.750]
        
        Oncogene Protein pp60(v-src) [D12.776.964.700.750.760]
        
        Oncogene Protein v-maf [D12.776.964.700.750.817]
        
        Oncogene Proteins v-abl [D12.776.964.700.750.875]
        
        Oncogene Proteins v-erbA [D12.776.964.700.750.882]
        
        Oncogene Proteins v-erbB [D12.776.964.700.750.883]
        
        Oncogene Proteins v-fos [D12.776.964.700.750.887]
        
        Oncogene Proteins v-mos [D12.776.964.700.750.900]
        
        Oncogene Proteins v-myb [D12.776.964.700.750.903]
        
        Oncogene Proteins v-raf [D12.776.964.700.750.920]
        
        Oncogene Proteins v-rel [D12.776.964.700.750.925]
        
        Oncogene Proteins v-sis [D12.776.964.700.750.935]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Retroviridae Proteins [D12.776.964.775]
      - Retroviridae Proteins, Oncogenic [D12.776.964.775.750]
        
        Fusion Proteins, gag-onc [D12.776.964.775.750.320]
        
        Gene Products, rex [D12.776.964.775.750.470]
        
        Gene Products, tax [D12.776.964.775.750.480]
        
        Oncogene Protein gp140(v-fms) [D12.776.964.775.750.650]
        
        Oncogene Protein p21(ras) [D12.776.964.775.750.710]
        
        Oncogene Protein p55(v-myc) [D12.776.964.775.750.750]
        
        Oncogene Protein pp60(v-src) [D12.776.964.775.750.760]
        
        Oncogene Protein v-maf [D12.776.964.775.750.817]
        
        Oncogene Proteins v-abl [D12.776.964.775.750.875]
        
        Oncogene Proteins v-erbA [D12.776.964.775.750.882]
        
        Oncogene Proteins v-erbB [D12.776.964.775.750.883]
        
        Oncogene Proteins v-fos [D12.776.964.775.750.887]
        
        Oncogene Proteins v-mos [D12.776.964.775.750.900]
        
        Oncogene Proteins v-myb [D12.776.964.775.750.903]
        
        Oncogene Proteins v-raf [D12.776.964.775.750.920]
        
        Oncogene Proteins v-rel [D12.776.964.775.750.925]
        
        Oncogene Proteins v-sis [D12.776.964.775.750.935]

Oncogene Protein pp60(v-src) Preferred

Concept UI: M0024064
Scope Note: A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.
Terms: Oncogene Protein pp60(v-src) Preferred Term
Term UI T046485
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1990); Oncogene Protein pp60(src)
Term UI T046478
Date05/18/1990
LexicalTag NON
ThesaurusID NLM (1991); src Oncogene Protein pp60
Term UI T046479
Date05/02/1990
LexicalTag NON
ThesaurusID NLM (1991); Oncogene Protein src
Term UI T046480
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); p60(v-src)
Term UI T046481
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); pp60 v-src
Term UI T046482
Date05/02/1990
LexicalTag NON
ThesaurusID NLM (1991); pp60(v-src)
Term UI T046483
Date05/02/1990
LexicalTag NON
ThesaurusID NLM (1991); v-src Protein
Term UI T046484
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); Phosphoprotein pp60(v-src)
Term UI T046486
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); Rous Sarcoma Virus-Transforming Protein pp60(v-src)
Term UI T046487
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); src Oncogene Product pp60
Term UI T046488
Date05/02/1990
LexicalTag NON
ThesaurusID NLM (1991); Avian Sarcoma Virus-Transforming Protein
Term UI T046477
Date02/10/1989
LexicalTag NON
ThesaurusID NLM (1990); v-src Protein pp60
Term UI T046489
Date05/02/1990
LexicalTag NON
ThesaurusID NLM (1991)

Oncogene Protein pp60(v-src) MeSH Descriptor Data 2025