MeSH Browser

MeSH Heading: src-Family Kinases
Tree Number(s): D08.811.913.696.620.682.725.800; D12.776.476.568.800
Unique ID: D019061
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019061
Scope Note: A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Entry Term(s): Protein-Tyrosine Kinases, src; Src Family Tyrosine Kinase; src Kinase; src Kinases; src Tyrosine Kinase; src Tyrosine Kinases; src-Family Kinase; src-Family Tyrosine Kinase; src-Family Tyrosine Kinases
Registry Numbers: EC 2.7.10.2
Previous Indexing: Protein-Tyrosine Kinase (1986-1995)
See Also: src Homology Domains
Public MeSH Note: 96
History Note: 96
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Agammaglobulinaemia Tyrosine Kinase [D08.811.913.696.620.682.725.025]
        
        Dyrk Kinases [D08.811.913.696.620.682.725.037]
        
        Focal Adhesion Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.049]
        
        Janus Kinases [D08.811.913.696.620.682.725.124]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
        
        Proto-Oncogene Proteins c-fes [D08.811.913.696.620.682.725.300]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Proto-Oncogene Proteins c-abl [D08.811.913.696.620.682.725.500]
        
        Syk Kinase [D08.811.913.696.620.682.725.650]
        
        src-Family Kinases [D08.811.913.696.620.682.725.800]
        
        CSK Tyrosine-Protein Kinase [D08.811.913.696.620.682.725.800.158]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D08.811.913.696.620.682.725.800.315]
        
        Oncogene Protein pp60(v-src) [D08.811.913.696.620.682.725.800.472]
        
        Proto-Oncogene Proteins c-fyn [D08.811.913.696.620.682.725.800.551]
        
        Proto-Oncogene Proteins c-hck [D08.811.913.696.620.682.725.800.590]
        
        Proto-Oncogene Proteins c-yes [D08.811.913.696.620.682.725.800.610]
        
        Proto-Oncogene Proteins pp60(c-src) [D08.811.913.696.620.682.725.800.630]
        
        ZAP-70 Protein-Tyrosine Kinase [D08.811.913.696.620.682.725.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]

src-Family Kinases Preferred

Concept UI: M0028454
Registry Numbers: EC 2.7.10.2
Scope Note: A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Terms: src-Family Kinases Preferred Term
Term UI T056935
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1996); src-Family Kinase
Term UI T000998454
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); src Kinase
Term UI T000998455
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); src Tyrosine Kinase
Term UI T000998456
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); src-Family Tyrosine Kinase
Term UI T000999147
Date11/22/2019
LexicalTag NON
ThesaurusID NLM (2021); src-Family Tyrosine Kinases
Term UI T056936
Date02/03/1995
LexicalTag NON
ThesaurusID NLM (1996); src Kinases
Term UI T363585
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Protein-Tyrosine Kinases, src
Term UI T363586
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Src Family Tyrosine Kinase
Term UI T000998453
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); src Tyrosine Kinases
Term UI T363587
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000)

src-Family Kinases MeSH Descriptor Data 2025