MeSH Browser

MeSH Heading: 2-Amino-5-phosphonovalerate
Tree Number(s): D12.125.070.950.100; D12.125.740.025
Unique ID: D015763
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015763
Scope Note: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Entry Term(s): 2-APV; 2-Amino-5-phosphonopentanoate; 2-Amino-5-phosphonopentanoic Acid; 2-Amino-5-phosphonovaleric Acid; 5-Phosphononorvaline; d-APV; dl-APV
Pharm Action: Excitatory Amino Acid Antagonists
Registry Number: 76726-92-6
CAS Type 1 Name: Norvaline, 5-phosphono-
Previous Indexing: Anticonvulsants (1966-1989); Valine (1966-1974); Valine/analogs & derivatives (1975-1989)
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2007/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0024150
Registry Number: 76726-92-6
Scope Note: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Terms: 2-Amino-5-phosphonovalerate Preferred Term
Term UI T046744
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); 5-Phosphononorvaline
Term UI T046748
Date03/28/1994
LexicalTag NON
ThesaurusID NLM (1995); 2-Amino-5-phosphonovaleric Acid
Term UI T046745
Date03/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 2-APV
Term UI T046746
Date03/03/1989
LexicalTag ABB
ThesaurusID NLM (1990); 2-Amino-5-phosphonopentanoate
Term UI T046742
Date03/03/1989
LexicalTag NON
ThesaurusID NLM (1990); 2-Amino-5-phosphonopentanoic Acid
Term UI T046743
Date03/03/1989
LexicalTag NON
ThesaurusID NLM (1990)

2-Amino-5-phosphonovalerate MeSH Descriptor Data 2023