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Didanosine MeSH Descriptor Data 2022


MeSH Heading
Didanosine
Tree Number(s)
D03.633.100.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
Unique ID
D016049
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016049
Scope Note
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Entry Term(s)
2',3'-Dideoxyinosine
Dideoxyinosine
NSC-612049
Videx
ddI (Antiviral)
Pharm Action
Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Registry Number
K3GDH6OH08
Related Numbers
69655-05-6
CAS Type 1 Name
Inosine, 2',3'-dideoxy-
Previous Indexing
Dideoxynucleosides (1989)
Inosine/analogs & derivatives (1987-1989)
Public MeSH Note
92; was DIDEOXYINOSINE 1990-91
Online Note
use DIDANOSINE to search DIDEOXYINOSINE 1990-91
History Note
92; was DIDEOXYINOSINE 1990-91
Date Established
1990/01/01
Date of Entry
1989/07/14
Revision Date
2017/05/24
Didanosine Preferred
Videx Narrower
NSC-612049 Narrower
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