- Concept UI
- M0023377
- Registry Numbers
- 4B9XT59T7S
- Related Numbers
- 30516-87-1
- Scope Note
- A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
- Terms
-
Zidovudine
Preferred Term
Term UI
T044495
Date01/01/1999
LexicalTag
NON
ThesaurusID
-
Azidothymidine
Term UI
T044490
Date05/09/1988
LexicalTag
NON
ThesaurusID
-
AZT Antiviral
Term UI
T044491
Date05/09/1988
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
3'-Azido-2',3'-Dideoxythymidine
Term UI
T044489
Date05/09/1988
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
AZT (Antiviral)
Term UI
T044493
Date05/09/1988
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
3'-Azido-3'-deoxythymidine
Term UI
T044497
Date07/13/1995
LexicalTag
NON
ThesaurusID
-
AZT, Antiviral
Term UI
T044492
Date05/09/1988
LexicalTag
NON
ThesaurusID
UNK (19XX)