NLM Logo

Dideoxynucleosides MeSH Descriptor Data 2023


MeSH Heading
Dideoxynucleosides
Tree Number(s)
D13.570.230.500
Unique ID
D015224
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015224
Annotation
antivirals & antimetabolites
Scope Note
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Entry Term(s)
2',3'-Dideoxynucleosides
Dideoxyribonucleosides
ddNus
Pharm Action
Antimetabolites
Antiviral Agents
Reverse Transcriptase Inhibitors
Registry Number
0
Previous Indexing
Deoxyribonucleosides (1971-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/05/12
Revision Date
1995/06/08
Dideoxynucleosides Preferred
2',3'-Dideoxynucleosides Narrower
Dideoxyribonucleosides Narrower
page delivered in 0.164s