MeSH Browser

MeSH Heading: MELAS Syndrome
Tree Number(s): C05.651.460.620.520; C10.228.140.163.100.535; C10.228.140.300.275.500; C10.668.491.500.500.500; C14.907.253.329.500; C16.320.565.189.535; C18.452.132.100.535; C18.452.648.189.535; C18.452.660.560.620.520
Unique ID: D017241
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017241
Scope Note: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
Entry Term(s): MELAS; Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes; Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes; Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode; Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Previous Indexing: Acidosis (1985-1986); Acidosis, Lactic (1987-1992); Brain Diseases (1985-1987); Brain Diseases, Metabolic (1987-1992); Cerebrovascular Disorders (1987-1992); Lactates (1985-1986); Mitochondria, Muscle (1984-1992); Neuromuscular Diseases (1987-1992)
Public MeSH Note: 1993
History Note: 1993
Date Established: 1993/01/01
Date of Entry: 1992/05/22
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]
  - Mitochondrial Myopathies [C05.651.460]
    - Mitochondrial Encephalomyopathies [C05.651.460.620]
      - MELAS Syndrome [C05.651.460.620.520]
      - MERRF Syndrome [C05.651.460.620.530]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Brain Diseases, Metabolic [C10.228.140.163]
      - Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
        
        Adrenoleukodystrophy [C10.228.140.163.100.084]
        
        Cerebral Amyloid Angiopathy, Familial [C10.228.140.163.100.168]
        
        Galactosemias [C10.228.140.163.100.320]
        
        Hartnup Disease [C10.228.140.163.100.355]
        
        Hepatolenticular Degeneration [C10.228.140.163.100.360]
        
        Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.163.100.362]
        
        Homocystinuria [C10.228.140.163.100.365]
        
        Hyperglycinemia, Nonketotic [C10.228.140.163.100.375]
        
        Hyperlysinemias [C10.228.140.163.100.380]
        
        Leigh Disease [C10.228.140.163.100.412]
        
        Lesch-Nyhan Syndrome [C10.228.140.163.100.425]
        
        Lysosomal Storage Diseases, Nervous System [C10.228.140.163.100.435]
        
        Maple Syrup Urine Disease [C10.228.140.163.100.520]
        
        MELAS Syndrome [C10.228.140.163.100.535]
        
        Menkes Kinky Hair Syndrome [C10.228.140.163.100.540]
        
        MERRF Syndrome [C10.228.140.163.100.545]
        
        Mevalonate Kinase Deficiency [C10.228.140.163.100.593]
        
        Oculocerebrorenal Syndrome [C10.228.140.163.100.640]
        
        Phenylketonurias [C10.228.140.163.100.687]
        
        Pyruvate Carboxylase Deficiency Disease [C10.228.140.163.100.725]
        
        Pyruvate Dehydrogenase Complex Deficiency Disease [C10.228.140.163.100.750]
        
        Refsum Disease [C10.228.140.163.100.813]
        
        Refsum Disease, Infantile [C10.228.140.163.100.844]
        
        Tyrosinemias [C10.228.140.163.100.875]
        
        Urea Cycle Disorders, Inborn [C10.228.140.163.100.937]
        
        Zellweger Syndrome [C10.228.140.163.100.968]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Cerebrovascular Disorders [C10.228.140.300]
      - Cerebral Small Vessel Diseases [C10.228.140.300.275]
        
        CADASIL [C10.228.140.300.275.249]
        
        Cerebral Amyloid Angiopathy, Familial [C10.228.140.300.275.311]
        
        Fabry Disease [C10.228.140.300.275.374]
        
        MELAS Syndrome [C10.228.140.300.275.500]
        
        Microscopic Polyangiitis [C10.228.140.300.275.600]
        
        Stroke, Lacunar [C10.228.140.300.275.800]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Muscular Diseases [C10.668.491]
    - Mitochondrial Myopathies [C10.668.491.500]
      - Mitochondrial Encephalomyopathies [C10.668.491.500.500]
        
        MELAS Syndrome [C10.668.491.500.500.500]
        
        MERRF Syndrome [C10.668.491.500.500.550]

Cardiovascular Diseases [C14]
- Vascular Diseases [C14.907]
  - Cerebrovascular Disorders [C14.907.253]
    - Cerebral Small Vessel Diseases [C14.907.253.329]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Brain Diseases, Metabolic, Inborn [C16.320.565.189]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Brain Diseases, Metabolic [C18.452.132]
    - Brain Diseases, Metabolic, Inborn [C18.452.132.100]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Brain Diseases, Metabolic, Inborn [C18.452.648.189]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Mitochondrial Diseases [C18.452.660]
    - Mitochondrial Myopathies [C18.452.660.560]
      - Mitochondrial Encephalomyopathies [C18.452.660.560.620]
        
        MELAS Syndrome [C18.452.660.560.620.520]
        
        MERRF Syndrome [C18.452.660.560.620.530]

MELAS Syndrome Preferred

Concept UI: M0026161
Scope Note: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
Terms: MELAS Syndrome Preferred Term
Term UI T051400
Date01/01/1999
LexicalTag ACX
ThesaurusID; Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Term UI T369339
Date11/03/1999
LexicalTag NON
ThesaurusID; Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Term UI T842019
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); MELAS
Term UI T844122
Date05/14/2013
LexicalTag NON
ThesaurusID GHR (2014); Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes
Term UI T842017
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Term UI T812059
Date11/15/2011
LexicalTag NON
ThesaurusID

MELAS Syndrome MeSH Descriptor Data 2025