MeSH Browser

MeSH Heading: Th1 Cells
Tree Number(s): A11.118.637.555.567.550.500.400.900; A11.118.637.555.567.569.200.400.900; A11.118.637.555.567.569.500.400.900; A15.145.229.637.555.567.550.500.400.500; A15.145.229.637.555.567.569.200.400.500; A15.145.229.637.555.567.569.500.400.500; A15.382.490.555.567.550.500.400.900; A15.382.490.555.567.569.200.400.900; A15.382.490.555.567.569.500.400.900
Unique ID: D018417
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018417
Scope Note: A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Entry Term(s): T Helper 1 Cells; TH-1 Cells; Type 1 Helper T Cells
Previous Indexing: T-Lymphocyte Subsets (1991-1994); T-Lymphocytes, Helper-Inducer (1985-1994)
Public MeSH Note: 95
History Note: 95
Date Established: 1995/01/01
Date of Entry: 1994/05/12
Revision Date: 2016/07/05

Allowable Qualifiers: chemistry (CH)

classification (CL)

cytology (CY)

drug effects (DE)

enzymology (EN)

immunology (IM)

metabolism (ME)

microbiology (MI)

parasitology (PS)

pathology (PA)

physiology (PH)

radiation effects (RE)

transplantation (TR)

ultrastructure (UL)

virology (VI)

Cells [A11]
- Blood Cells [A11.118]
  - Leukocytes [A11.118.637]
    - Leukocytes, Mononuclear [A11.118.637.555]
      - Lymphocytes [A11.118.637.555.567]
        
        Lymphocyte Subsets [A11.118.637.555.567.550]
        
        T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
        
        T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.550.500.400]
        
        T Follicular Helper Cells [A11.118.637.555.567.550.500.400.450]
        
        Th1 Cells [A11.118.637.555.567.550.500.400.900]
        
        Th2 Cells [A11.118.637.555.567.550.500.400.905]
        
        Th17 Cells [A11.118.637.555.567.550.500.400.915]

Cells [A11]
- Blood Cells [A11.118]
  - Leukocytes [A11.118.637]
    - Leukocytes, Mononuclear [A11.118.637.555]
      - Lymphocytes [A11.118.637.555.567]
        
        T-Lymphocytes [A11.118.637.555.567.569]
        
        CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
        
        T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.200.400]
        
        T Follicular Helper Cells [A11.118.637.555.567.569.200.400.450]
        
        Th1 Cells [A11.118.637.555.567.569.200.400.900]
        
        Th2 Cells [A11.118.637.555.567.569.200.400.905]
        
        Th17 Cells [A11.118.637.555.567.569.200.400.915]

Cells [A11]
- Blood Cells [A11.118]
  - Leukocytes [A11.118.637]
    - Leukocytes, Mononuclear [A11.118.637.555]
      - Lymphocytes [A11.118.637.555.567]
        
        T-Lymphocytes [A11.118.637.555.567.569]
        
        T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
        
        T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.500.400]
        
        T Follicular Helper Cells [A11.118.637.555.567.569.500.400.450]
        
        Th1 Cells [A11.118.637.555.567.569.500.400.900]
        
        Th2 Cells [A11.118.637.555.567.569.500.400.905]
        
        Th17 Cells [A11.118.637.555.567.569.500.400.915]

Hemic and Immune Systems [A15]
- Blood [A15.145]
  - Blood Cells [A15.145.229]
    - Leukocytes [A15.145.229.637]
      - Leukocytes, Mononuclear [A15.145.229.637.555]
        
        Lymphocytes [A15.145.229.637.555.567]
        
        Lymphocyte Subsets [A15.145.229.637.555.567.550]
        
        T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
        
        T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.550.500.400]
        
        T Follicular Helper Cells [A15.145.229.637.555.567.550.500.400.250]
        
        Th1 Cells [A15.145.229.637.555.567.550.500.400.500]
        
        Th2 Cells [A15.145.229.637.555.567.550.500.400.750]
        
        Th17 Cells [A15.145.229.637.555.567.550.500.400.770]

Hemic and Immune Systems [A15]
- Blood [A15.145]
  - Blood Cells [A15.145.229]
    - Leukocytes [A15.145.229.637]
      - Leukocytes, Mononuclear [A15.145.229.637.555]
        
        Lymphocytes [A15.145.229.637.555.567]
        
        T-Lymphocytes [A15.145.229.637.555.567.569]
        
        CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
        
        T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.200.400]
        
        T Follicular Helper Cells [A15.145.229.637.555.567.569.200.400.250]
        
        Th1 Cells [A15.145.229.637.555.567.569.200.400.500]
        
        Th2 Cells [A15.145.229.637.555.567.569.200.400.750]
        
        Th17 Cells [A15.145.229.637.555.567.569.200.400.770]

Hemic and Immune Systems [A15]
- Blood [A15.145]
  - Blood Cells [A15.145.229]
    - Leukocytes [A15.145.229.637]
      - Leukocytes, Mononuclear [A15.145.229.637.555]
        
        Lymphocytes [A15.145.229.637.555.567]
        
        T-Lymphocytes [A15.145.229.637.555.567.569]
        
        T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
        
        T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.500.400]
        
        Th1 Cells [A15.145.229.637.555.567.569.500.400.500]
        
        Th2 Cells [A15.145.229.637.555.567.569.500.400.750]
        
        Th17 Cells [A15.145.229.637.555.567.569.500.400.770]

Hemic and Immune Systems [A15]
- Immune System [A15.382]
  - Leukocytes [A15.382.490]
    - Leukocytes, Mononuclear [A15.382.490.555]
      - Lymphocytes [A15.382.490.555.567]
        
        Lymphocyte Subsets [A15.382.490.555.567.550]
        
        T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
        
        T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.550.500.400]
        
        T Follicular Helper Cells [A15.382.490.555.567.550.500.400.450]
        
        Th1 Cells [A15.382.490.555.567.550.500.400.900]
        
        Th2 Cells [A15.382.490.555.567.550.500.400.905]
        
        Th17 Cells [A15.382.490.555.567.550.500.400.915]

Hemic and Immune Systems [A15]
- Immune System [A15.382]
  - Leukocytes [A15.382.490]
    - Leukocytes, Mononuclear [A15.382.490.555]
      - Lymphocytes [A15.382.490.555.567]
        
        T-Lymphocytes [A15.382.490.555.567.569]
        
        CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
        
        T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.200.400]
        
        T Follicular Helper Cells [A15.382.490.555.567.569.200.400.450]
        
        Th1 Cells [A15.382.490.555.567.569.200.400.900]
        
        Th2 Cells [A15.382.490.555.567.569.200.400.905]
        
        Th17 Cells [A15.382.490.555.567.569.200.400.915]

Hemic and Immune Systems [A15]
- Immune System [A15.382]
  - Leukocytes [A15.382.490]
    - Leukocytes, Mononuclear [A15.382.490.555]
      - Lymphocytes [A15.382.490.555.567]
        
        T-Lymphocytes [A15.382.490.555.567.569]
        
        T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
        
        T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.500.400]
        
        T Follicular Helper Cells [A15.382.490.555.567.569.500.400.450]
        
        Th1 Cells [A15.382.490.555.567.569.500.400.900]
        
        Th2 Cells [A15.382.490.555.567.569.500.400.905]
        
        Th17 Cells [A15.382.490.555.567.569.500.400.915]

Th1 Cells Preferred

Concept UI: M0027645
Scope Note: A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Terms: Th1 Cells Preferred Term
Term UI T054899
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1995); TH-1 Cells
Term UI T000898307
Date04/05/2016
LexicalTag ABX
ThesaurusID NLM (2017); T Helper 1 Cells
Term UI T000898305
Date04/05/2016
LexicalTag NON
ThesaurusID NLM (2017); Type 1 Helper T Cells
Term UI T000898306
Date04/05/2016
LexicalTag NON
ThesaurusID NLM (2017)

Th1 Cells MeSH Descriptor Data 2023