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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization MeSH Descriptor Data 2026


MeSH Heading
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tree Number(s)
E05.196.566.755
Unique ID
D019032
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019032
Scope Note
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Entry Term(s)
Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted
MALD-MS
MALDI
MALDI-MS
MS-MALD
Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization
Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
SELDI-TOF-MS
Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization
Surface Enhanced Laser Desorption Ionization Mass Spectrometry
Previous Indexing
Spectrum Analysis, Mass (1989-1995)
Public MeSH Note
96
History Note
96
Date Introduced
1996/01/01
Last Updated
2006/07/05
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Preferred
Surface Enhanced Laser Desorption Ionization Mass Spectrometry Narrower
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