MeSH Browser

MeSH Heading: GTP-Binding Protein alpha Subunits, Gi-Go
Tree Number(s): D08.811.277.040.330.300.200.100.200; D12.776.157.325.332.100.200; D12.776.476.338.200.100.200; D12.776.543.325.100.200
Unique ID: D019206
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019206
Scope Note: A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to inhibit ADENYLYL CYCLASES. Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.
Entry Term(s): G Protein Go; G Protein Subunit alphaoA; G Protein Subunit alphaoC; G(o) Protein; G(o1)alpha; G-Protein, Gi Subunit; G-Protein, Gi-Go Subunits; G-Protein, Gi-Go alpha Family; G-Protein, Go Subunit; G-Protein, Go1 Subunit; G-Protein, Inhibitory Gi; G-Protein, Inhibitory Go; GTP-Binding Protein alpha Subunit, Gi; GTP-Binding Protein alpha Subunit, Go; GTP-Binding Protein alpha Subunit, Go1; GTP-Binding Protein alpha Subunit, GoA; GTP-Binding Protein alpha Subunit, GoC; Gi alpha Subunit; Gi, Inhibitory G-Protein; Gi-Alpha Protein; Gi-Go G-Proteins; Go Alpha Subunit; Guanine Nucleotide-Binding Protein Go; Ni Protein
Related Numbers: EC 3.6.5.1
Previous Indexing: G-Proteins (1985-1996)
Public MeSH Note: 2004; see G-PROTEIN, INHBITORY GI 1997-2003; GUANINE NUCLEOTIDE-BINDING PROTEIN GO was indexed under HETEROTRIMERIC GTP-BINDING PROTEINS 2000-2003 & GTP-BINDING PROTEINS 1991-1999
History Note: 2004(1997); for GUANINE NUCLEOTIDE-BINDING PROTEIN GO use GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO (NM) 1997-2003
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - GTP Phosphohydrolases [D08.811.277.040.330]
        
        GTP-Binding Proteins [D08.811.277.040.330.300]
        
        Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
        
        GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D08.811.277.040.330.300.200.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D08.811.277.040.330.300.200.100.200]
        
        GTP-Binding Protein alpha Subunit, Gi2 [D08.811.277.040.330.300.200.100.200.500]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D08.811.277.040.330.300.200.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D08.811.277.040.330.300.200.100.400]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - GTP-Binding Proteins [D12.776.157.325]
      - Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
        
        GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D12.776.157.325.332.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.157.325.332.100.200]
        
        GTP-Binding Protein alpha Subunit, Gi2 [D12.776.157.325.332.100.200.500]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.157.325.332.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D12.776.157.325.332.100.400]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - GTP-Binding Proteins [D12.776.476.338]
      - Heterotrimeric GTP-Binding Proteins [D12.776.476.338.200]
        
        GTP-Binding Protein alpha Subunits [D12.776.476.338.200.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D12.776.476.338.200.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.476.338.200.100.200]
        
        GTP-Binding Protein alpha Subunit, Gi2 [D12.776.476.338.200.100.200.500]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.476.338.200.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D12.776.476.338.200.100.400]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
      - GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D12.776.543.325.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.543.325.100.200]
        
        GTP-Binding Protein alpha Subunit, Gi2 [D12.776.543.325.100.200.500]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.543.325.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D12.776.543.325.100.400]

GTP-Binding Protein alpha Subunits, Gi-Go Preferred

Concept UI: M0444924
Related Numbers: EC 3.6.5.1
Scope Note: A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to inhibit ADENYLYL CYCLASES. Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.
Terms: GTP-Binding Protein alpha Subunits, Gi-Go Preferred Term
Term UI T530931
Date01/24/2003
LexicalTag ABX
ThesaurusID NLM (2004); G-Protein, Gi-Go alpha Family
Term UI T530748
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004); G-Protein, Gi-Go Subunits
Term UI T530753
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004); Gi-Go G-Proteins
Term UI T530940
Date01/24/2003
LexicalTag ABX
ThesaurusID NLM (2004)

GTP-Binding Protein alpha Subunit, Gi Narrower

Concept UI: M0028610
Terms: GTP-Binding Protein alpha Subunit, Gi Preferred Term
Term UI T531310
Date01/29/2003
LexicalTag ABX
ThesaurusID NLM (2004); Gi, Inhibitory G-Protein
Term UI T057221
Date09/13/1995
LexicalTag ABX
ThesaurusID NLM (1997); G-Protein, Inhibitory Gi
Term UI T057222
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1997); Ni Protein
Term UI T057220
Date02/01/1996
LexicalTag ABX
ThesaurusID NLM (1997); G-Protein, Gi Subunit
Term UI T530754
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004); Gi alpha Subunit
Term UI T530755
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004); Gi-Alpha Protein
Term UI T456453
Date08/07/2001
LexicalTag NON
ThesaurusID NLM (2006)

GTP-Binding Protein alpha Subunit, GoA Narrower

GTP-Binding Protein alpha Subunit, GoC Narrower

GTP-Binding Protein alpha Subunit, Go1 Narrower

GTP-Binding Protein alpha Subunit, Go Narrower

Concept UI: M0444929
Terms: GTP-Binding Protein alpha Subunit, Go Preferred Term
Term UI T531311
Date01/29/2003
LexicalTag ABX
ThesaurusID NLM (2004); Guanine Nucleotide-Binding Protein Go
Term UI T218766
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); G(o) Protein
Term UI T423184
Date09/02/2000
LexicalTag ABX
ThesaurusID NLM (2004); G Protein Go
Term UI T218762
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); G-Protein, Go Subunit
Term UI T530757
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004); Go Alpha Subunit
Term UI T530758
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004); G-Protein, Inhibitory Go
Term UI T530756
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004)

GTP-Binding Protein alpha Subunits, Gi-Go MeSH Descriptor Data 2025