MeSH Browser

MeSH Heading: GTP-Binding Protein alpha Subunits, G12-G13
Tree Number(s): D08.811.277.040.330.300.200.100.100; D12.776.157.325.332.100.100; D12.776.476.338.200.100.100; D12.776.543.325.100.100
Unique ID: D044365
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D044365
Scope Note: A ubiquitously expressed family of heterotrimeric GTP-binding protein alpha subunits that signal through interactions with a variety of second messengers as GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; and HEAT SHOCK PROTEINS. The G12-G13 part of the name is also spelled G12/G13.
Entry Term(s): G alpha12 Protein; G alpha13 Protein; G(13) Protein; G-Protein, G12 Subunit; G-Protein, G12-G13 alpha Family; G-Protein, G12-G13 alpha Subunits; G-Protein, G13 Subunit; G12 Protein; G12 alpha Protein; G13 G-Protein; G13 Protein; GTP-Binding Protein alpha Subunit, G12; GTP-Binding Protein alpha Subunit, G13; Galpha12 Protein; Galpha13 Protein
Related Numbers: EC 3.6.5.1
Previous Indexing: GTP-Binding Proteins (1991-2003); Heterotrimeric GTP-Binding Proteins (2000-2003)
Public MeSH Note: 2004; G ALPHA12 PROTEIN was indexed under HETEROTRIMERIC GTP-BINDING PROTEINS 2000-2003; G13 PROTEIN was indexed under DNA-BINDING PROTEINS 1996-2003; G(13) PROTEIN was indexed under HETEROTRIMERIC GTP-BINDING PROTEINS 2000-2003 & GTP-BINDING PROTEINS 1998-1999
History Note: 2004; use GTP-BINDING PROTEIN, G12-13 ALPHA SUBUNITS (NM) 1996-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - GTP Phosphohydrolases [D08.811.277.040.330]
        
        GTP-Binding Proteins [D08.811.277.040.330.300]
        
        Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
        
        GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D08.811.277.040.330.300.200.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D08.811.277.040.330.300.200.100.200]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D08.811.277.040.330.300.200.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D08.811.277.040.330.300.200.100.400]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - GTP-Binding Proteins [D12.776.157.325]
      - Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
        
        GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D12.776.157.325.332.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.157.325.332.100.200]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.157.325.332.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D12.776.157.325.332.100.400]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - GTP-Binding Proteins [D12.776.476.338]
      - Heterotrimeric GTP-Binding Proteins [D12.776.476.338.200]
        
        GTP-Binding Protein alpha Subunits [D12.776.476.338.200.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D12.776.476.338.200.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.476.338.200.100.200]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.476.338.200.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D12.776.476.338.200.100.400]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
      - GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
        
        GTP-Binding Protein alpha Subunits, G12-G13 [D12.776.543.325.100.100]
        
        GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.543.325.100.200]
        
        GTP-Binding Protein alpha Subunits, Gq-G11 [D12.776.543.325.100.300]
        
        GTP-Binding Protein alpha Subunits, Gs [D12.776.543.325.100.400]

GTP-Binding Protein alpha Subunits, G12-G13 Preferred

GTP-Binding Protein alpha Subunit, G13 Narrower

Concept UI: M0267113
Terms: GTP-Binding Protein alpha Subunit, G13 Preferred Term
Term UI T531292
Date01/29/2003
LexicalTag ACX
ThesaurusID NLM (2004); G13 Protein
Term UI T297118
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); G-Protein, G13 Subunit
Term UI T530774
Date01/22/2003
LexicalTag ABX
ThesaurusID NLM (2004); G(13) Protein
Term UI T317494
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); G alpha13 Protein
Term UI T443820
Date04/21/2001
LexicalTag ABX
ThesaurusID NLM (2004); Galpha13 Protein
Term UI T443821
Date04/21/2001
LexicalTag ABX
ThesaurusID NLM (2004); G13 G-Protein
Term UI T317493
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004)

GTP-Binding Protein alpha Subunit, G12 Narrower

Concept UI: M0368030
Terms: GTP-Binding Protein alpha Subunit, G12 Preferred Term
Term UI T531291
Date01/29/2003
LexicalTag ABX
ThesaurusID NLM (2004); G-Protein, G12 Subunit
Term UI T530773
Date01/22/2003
LexicalTag NON
ThesaurusID NLM (2004); G12 Protein
Term UI T533709
Date02/26/2003
LexicalTag NON
ThesaurusID NLM (2004); G alpha12 Protein
Term UI T421848
Date08/16/2000
LexicalTag NON
ThesaurusID NLM (2004); G12 alpha Protein
Term UI T421849
Date08/16/2000
LexicalTag NON
ThesaurusID NLM (2004); Galpha12 Protein
Term UI T499961
Date06/22/2002
LexicalTag NON
ThesaurusID NLM (2004)

GTP-Binding Protein alpha Subunits, G12-G13 MeSH Descriptor Data 2025