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MPTP Poisoning MeSH Descriptor Data 2023


MeSH Heading
MPTP Poisoning
Tree Number(s)
C10.228.140.079.862.800.300
C10.228.662.600.700.250
C10.720.606
C25.723.705.400
Unique ID
D020267
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020267
Annotation
not for animal models of Parkinson disease induced by MPTP: index MPTP-INDUCED EXPERIMENTAL PARKINSONISM
Scope Note
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Entry Version
MPTP POIS
Entry Term(s)
MPTP Neurotoxicity Syndrome
MPTP-Induced Degeneration of the Striatum
MPTP-Induced Parkinsonism
Neurotoxicity Syndrome, MPTP
Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Previous Indexing
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/poisoning (1990-1999)
Parkinson Disease, Secondary (1983-1999)
See Also
1-Methyl-4-phenylpyridinium
Public MeSH Note
2000
History Note
2000
Date Established
2000/01/01
Date of Entry
1999/11/08
Revision Date
2010/06/25
MPTP Poisoning Preferred
MPTP-Induced Degeneration of the Striatum Narrower
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