MeSH Browser

MeSH Heading: MPTP Poisoning
Tree Number(s): C10.228.140.079.862.800.300; C10.228.662.600.700.250; C10.720.606; C25.723.705.400
Unique ID: D020267
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020267
Annotation: not for animal models of Parkinson disease induced by MPTP: index MPTP-INDUCED EXPERIMENTAL PARKINSONISM
Scope Note: A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Entry Version: MPTP POIS
Entry Term(s): MPTP Neurotoxicity Syndrome; MPTP-Induced Degeneration of the Striatum; MPTP-Induced Parkinsonism; Neurotoxicity Syndrome, MPTP; Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Previous Indexing: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/poisoning (1990-1999); Parkinson Disease, Secondary (1983-1999)
See Also: 1-Methyl-4-phenylpyridinium
Public MeSH Note: 2000
History Note: 2000
Date Established: 2000/01/01
Date of Entry: 1999/11/08
Revision Date: 2010/06/25

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

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Concept UI: M0328147
Scope Note: A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Terms: MPTP Poisoning Preferred Term
Term UI T358147
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Term UI T364552
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MPTP Neurotoxicity Syndrome
Term UI T364551
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MPTP-Induced Parkinsonism
Term UI T364553
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Neurotoxicity Syndrome, MPTP
Term UI T364554
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

MPTP Poisoning MeSH Descriptor Data 2025