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A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (ERB-B2 RECEPTOR TYROSINE KINASES). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.
Entry Term(s)
GGF Protein
Glial Growth Factor
Heregulin
NDF Protein
NRG1 Protein
neu Differentiation Factor
Registry Numbers
0
Previous Indexing
Glycoproteins (1986-1999)
Nerve Tissue Proteins (1980-1999)
Public MeSH Note
2000; NEUREGULIN-1 was indexed under GLYCOPROTEINS 1993-1999; GLIAL GROWTH FACTOR was indexed under NERVE TISSUE PROTEINS 1980-1999
History Note
2000; use NEUREGULIN-1 (NM) 1993-1999; for GLIAL GROWTH FACTOR use GLIA MATURATION FACTOR (NM) 1980-1999
A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (ERB-B2 RECEPTOR TYROSINE KINASES). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.