MeSH Browser

MeSH Heading: Sodium Channel Blockers
Tree Number(s): D27.505.519.562.750; D27.505.954.411.720
Unique ID: D026941
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D026941
Annotation: coordinate with DIURETICS if pertinent
Scope Note: A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Entry Version: NA CHANNEL BLOCK
Entry Term(s): Channel Blockers, Sodium; Sodium Channel Blocker; Sodium Channel Inhibitor; Sodium Channel Inhibitors
Registry Number: 0
Previous Indexing: Ion Channels (1982-1988); Sodium Channels/antagonists & inhibitors (1988-2001)
See Also: Anti-Arrhythmia Agents
Public MeSH Note: 2002
History Note: 2002
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0379271
Registry Number: 0
Scope Note: A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Terms: Sodium Channel Blockers Preferred Term
Term UI T436989
Date02/23/2001
LexicalTag NON
ThesaurusID NLM (2002); Sodium Channel Inhibitor
Term UI T000996725
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Sodium Channel Blocker
Term UI T000996724
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Channel Blockers, Sodium
Term UI T436990
Date02/23/2001
LexicalTag NON
ThesaurusID NLM (2002); Sodium Channel Inhibitors
Term UI T820337
Date04/04/2012
LexicalTag NON
ThesaurusID NLM (2013)

Sodium Channel Blockers MeSH Descriptor Data 2023