MeSH Browser

MeSH Heading: Sodium Chloride Symporter Inhibitors
Tree Number(s): D27.505.519.562.812; D27.505.696.560.500.863
Unique ID: D049993
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D049993
Scope Note: Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.
Entry Term(s): Benzothiadiazine Diuretic; Benzothiadiazine Diuretics; Diuretics, Thiazide; Potassium Depleting Diuretic; Potassium Depleting Diuretics; Sodium Chloride Cotransporter Inhibitor; Sodium Chloride Cotransporter Inhibitors; Sodium Chloride Symporter Inhibitor; Thiazide Diuretic; Thiazide Diuretics; Thiazide Sensitive NaCl Cotransporter Inhibitor; Thiazide Sensitive NaCl Cotransporter Inhibitors
Public MeSH Note: 2006; for THIAZIDE DIURETICS use THIAZIDE DIURETICS 1976-2005
History Note: 2006
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0006628
Scope Note: Diuretics characterized as analogs of 1,2,4-benzothiadiazine-1,1-dioxide. All have a common mechanism of action and differ primarily in the dose required to produce a given effect. They act directly on the kidney to increase the excretion of sodium chloride and water. Also, diuretics increase excretion of potassium ions.
Terms: Diuretics, Thiazide Preferred Term
Term UI T012863
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1974); Thiazide Diuretic
Term UI T000997935
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Benzothiadiazine Diuretics
Term UI T012861
Date03/29/1974
LexicalTag NON
ThesaurusID UNK (19XX); Thiazide Diuretics
Term UI T012862
Date03/05/1976
LexicalTag NON
ThesaurusID UNK (19XX); Benzothiadiazine Diuretic
Term UI T000997939
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021)

Sodium Chloride Symporter Inhibitors MeSH Descriptor Data 2025