MeSH Browser

MeSH Heading: Optic Atrophy, Autosomal Dominant
Tree Number(s): C10.292.700.225.500.100; C10.574.500.662.100; C11.270.564.100; C11.640.451.451.100; C16.320.290.564.100; C16.320.400.630.100; C18.452.660.665
Unique ID: D029241
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D029241
Scope Note: Dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (Hum. Genet. 1998; 102: 79-86). Mutations leading to this condition have been mapped to the OPA1 gene at chromosome 3q28-q29. OPA1 codes for a dynamin-related GTPase that localizes to mitochondria.
Entry Term(s): Autosomal Dominant Optic Atrophy; Autosomal Dominant Optic Atrophy Kjer Type; Dominant Optic Atrophy; Kjer Type Optic Atrophy; Kjer's Optic Atrophy; Kjer-Type Optic Atrophy; Optic Atrophy 1; Optic Atrophy Type 1; Optic Atrophy, Hereditary, Autosomal Dominant; Optic Atrophy, Juvenile; Optic Atrophy, Kjer Type
Previous Indexing: Optic Atrophy (1971-2001); Optic Atrophy, Hereditary (1989-2001)
Public MeSH Note: 2002; see OPTIC ATROPHIES, HEREDITARY 2000-2001
History Note: 2002; use OPTIC ATROPHIES, HEREDITARY 2000-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Cranial Nerve Diseases [C10.292]
  - Optic Nerve Diseases [C10.292.700]
    - Optic Atrophy [C10.292.700.225]
      - Optic Atrophies, Hereditary [C10.292.700.225.500]
        
        Optic Atrophy, Autosomal Dominant [C10.292.700.225.500.100]
        
        Optic Atrophy, Hereditary, Leber [C10.292.700.225.500.400]
        
        Wolfram Syndrome [C10.292.700.225.500.980]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]
    - Optic Atrophies, Hereditary [C10.574.500.662]

Eye Diseases [C11]
- Eye Diseases, Hereditary [C11.270]
  - Optic Atrophies, Hereditary [C11.270.564]

Eye Diseases [C11]
- Optic Nerve Diseases [C11.640]
  - Optic Atrophy [C11.640.451]
    - Optic Atrophies, Hereditary [C11.640.451.451]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Eye Diseases, Hereditary [C16.320.290]
    - Optic Atrophies, Hereditary [C16.320.290.564]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]
    - Optic Atrophies, Hereditary [C16.320.400.630]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Mitochondrial Diseases [C18.452.660]

Optic Atrophy, Autosomal Dominant Preferred

Concept UI: M0333666
Scope Note: Dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (Hum. Genet. 1998; 102: 79-86). Mutations leading to this condition have been mapped to the OPA1 gene at chromosome 3q28-q29. OPA1 codes for a dynamin-related GTPase that localizes to mitochondria.
Terms: Optic Atrophy, Autosomal Dominant Preferred Term
Term UI T365616
Date11/03/1999
LexicalTag NON
ThesaurusID; Optic Atrophy, Hereditary, Autosomal Dominant
Term UI T446828
Date05/16/2001
LexicalTag NON
ThesaurusID; Optic Atrophy, Juvenile
Term UI T812314
Date11/15/2011
LexicalTag NON
ThesaurusID; Optic Atrophy, Kjer Type
Term UI T443109
Date04/16/2001
LexicalTag NON
ThesaurusID; Autosomal Dominant Optic Atrophy Kjer Type
Term UI T842203
Date04/18/2013
LexicalTag EPO
ThesaurusID GHR (2014); Kjer Type Optic Atrophy
Term UI T842204
Date04/18/2013
LexicalTag EPO
ThesaurusID GHR (2014); Kjer's Optic Atrophy
Term UI T842205
Date04/18/2013
LexicalTag EPO
ThesaurusID GHR (2014); Autosomal Dominant Optic Atrophy
Term UI T365618
Date11/03/1999
LexicalTag NON
ThesaurusID; Dominant Optic Atrophy
Term UI T365617
Date11/03/1999
LexicalTag NON
ThesaurusID; Kjer-Type Optic Atrophy
Term UI T812313
Date11/15/2011
LexicalTag NON
ThesaurusID; Optic Atrophy Type 1
Term UI T443108
Date04/16/2001
LexicalTag NON
ThesaurusID; Optic Atrophy 1
Term UI T812311
Date11/15/2011
LexicalTag NON
ThesaurusID

Optic Atrophy, Autosomal Dominant MeSH Descriptor Data 2025