MeSH Browser

MeSH Heading: Optic Atrophy, Hereditary, Leber
Tree Number(s): C10.292.700.225.500.400; C10.574.500.662.400; C11.270.564.400; C11.640.451.451.400; C16.320.290.564.400; C16.320.400.630.400; C18.452.660.670
Unique ID: D029242
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D029242
Scope Note: A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))
Entry Term(s): Hereditary Optic Neuroretinopathy; Leber Hereditary Optic Atrophy; Leber Hereditary Optic Neuropathy; Leber Optic Atrophy; Leber Optic Atrophy and Dystonia; Leber's Disease; Leber's Hereditary Optic Atrophy; Leber's Hereditary Optic Neuropathy; Leber's Optic Atrophy; Leber's Optic Neuropathy; Optic Atrophy, Leber Type; Optic Atrophy, Leber, Hereditary
Previous Indexing: Optic Atrophies, Hereditary (1989-2001); Optic Atrophy/genetics (1977-1988)
Public MeSH Note: 2002; see OPTIC ATROPHIES, HEREDITARY 1999-2001
History Note: 2002; use OPTIC ATROPHIES, HEREDITARY 1999-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Cranial Nerve Diseases [C10.292]
  - Optic Nerve Diseases [C10.292.700]
    - Optic Atrophy [C10.292.700.225]
      - Optic Atrophies, Hereditary [C10.292.700.225.500]
        
        Optic Atrophy, Autosomal Dominant [C10.292.700.225.500.100]
        
        Optic Atrophy, Hereditary, Leber [C10.292.700.225.500.400]
        
        Wolfram Syndrome [C10.292.700.225.500.980]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]
    - Optic Atrophies, Hereditary [C10.574.500.662]

Eye Diseases [C11]
- Eye Diseases, Hereditary [C11.270]
  - Optic Atrophies, Hereditary [C11.270.564]

Eye Diseases [C11]
- Optic Nerve Diseases [C11.640]
  - Optic Atrophy [C11.640.451]
    - Optic Atrophies, Hereditary [C11.640.451.451]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Eye Diseases, Hereditary [C16.320.290]
    - Optic Atrophies, Hereditary [C16.320.290.564]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]
    - Optic Atrophies, Hereditary [C16.320.400.630]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Mitochondrial Diseases [C18.452.660]

Optic Atrophy, Hereditary, Leber Preferred

Concept UI: M0333667
Scope Note: A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))
Terms: Optic Atrophy, Hereditary, Leber Preferred Term
Term UI T446827
Date05/16/2001
LexicalTag NON
ThesaurusID NLM (2002); Leber Optic Atrophy and Dystonia
Term UI T751053
Date05/13/2009
LexicalTag EPO
ThesaurusID; Leber's Disease
Term UI T752613
Date06/10/2009
LexicalTag NON
ThesaurusID; Leber's Hereditary Optic Atrophy
Term UI T045532
Date04/13/1998
LexicalTag EPO
ThesaurusID NLM (1999); Leber's Hereditary Optic Neuropathy
Term UI T045531
Date04/13/1998
LexicalTag EPO
ThesaurusID; Leber's Optic Atrophy
Term UI T045526
Date04/13/1998
LexicalTag EPO
ThesaurusID; Leber's Optic Neuropathy
Term UI T843581
Date05/03/2013
LexicalTag EPO
ThesaurusID GHR (2014); Optic Atrophy, Leber Type
Term UI T752614
Date06/10/2009
LexicalTag EPO
ThesaurusID; Optic Atrophy, Leber, Hereditary
Term UI T446826
Date05/16/2001
LexicalTag NON
ThesaurusID NLM (2002); Hereditary Optic Neuroretinopathy
Term UI T841891
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Leber Hereditary Optic Atrophy
Term UI T045533
Date04/13/1998
LexicalTag EPO
ThesaurusID; Leber Optic Atrophy
Term UI T045527
Date04/13/1998
LexicalTag EPO
ThesaurusID; Leber Hereditary Optic Neuropathy
Term UI T045530
Date04/13/1998
LexicalTag EPO
ThesaurusID

Optic Atrophy, Hereditary, Leber MeSH Descriptor Data 2025