MeSH Browser

MeSH Heading: Poly(A)-Binding Protein II
Tree Number(s): D12.776.157.725.452.500; D12.776.664.962.452.500
Unique ID: D039103
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039103
Scope Note: A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Entry Term(s): PAB II; PAB2 Poly(A) Binding Protein; PABP2; Pabp2 Gene Product; Pabp2 Protein; Poly(A) Binding Protein II; Poly(A) Binding Protein, Nuclear 1
Registry Number: 0
Previous Indexing: RNA-Binding Proteins (1995-2002)
See Also: Muscular Dystrophy, Oculopharyngeal
Public MeSH Note: 2003; PAB II was indexed under RNA-BINDING PROTEINS 1995-2002; PABP2 GENE PRODUCT & PABP2 PROTEIN were indexed under RNA-BINDING PROTEINS 1999-2002; PABP2 was indexed under RNA-BINDING PROTEINS 2000-2002
History Note: 2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - RNA-Binding Proteins [D12.776.157.725]
      - Poly(A)-Binding Proteins [D12.776.157.725.452]
        
        Ataxin-2 [D12.776.157.725.452.125]
        
        Poly(A)-Binding Protein I [D12.776.157.725.452.249]
        
        Poly(A)-Binding Protein II [D12.776.157.725.452.500]
        
        T-Cell Intracellular Antigen-1 [D12.776.157.725.452.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nucleoproteins [D12.776.664]
    - RNA-Binding Proteins [D12.776.664.962]
      - Poly(A)-Binding Proteins [D12.776.664.962.452]
        
        Ataxin-2 [D12.776.664.962.452.125]
        
        Poly(A)-Binding Protein I [D12.776.664.962.452.249]
        
        Poly(A)-Binding Protein II [D12.776.664.962.452.500]
        
        T-Cell Intracellular Antigen-1 [D12.776.664.962.452.750]

Poly(A)-Binding Protein II Preferred

Concept UI: M0103425
Registry Number: 0
Scope Note: A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Terms: Poly(A)-Binding Protein II Preferred Term
Term UI T487260
Date03/25/2002
LexicalTag ACX
ThesaurusID NLM (2003); PAB2 Poly(A) Binding Protein
Term UI T486940
Date03/22/2002
LexicalTag ACX
ThesaurusID NLM (2003); Poly(A) Binding Protein, Nuclear 1
Term UI T486941
Date03/22/2002
LexicalTag ACX
ThesaurusID NLM (2003); Pabp2 Gene Product
Term UI T328010
LexicalTag ABX
ThesaurusID NLM (2003); Pabp2 Protein
Term UI T328011
LexicalTag ACX
ThesaurusID NLM (2003); Poly(A) Binding Protein II
Term UI T133439
LexicalTag ACX
ThesaurusID NLM (2003); PAB II
Term UI T133429
LexicalTag ACR
ThesaurusID NLM (2003); PABP2
Term UI T402766
Date12/15/1999
LexicalTag ACR
ThesaurusID NLM (2003)

Poly(A)-Binding Protein II MeSH Descriptor Data 2023