MeSH Browser

MeSH Heading: Cytochrome P-450 CYP4A
Tree Number(s): D08.244.453.870.500; D08.811.682.690.708.170.496.500; D12.776.422.220.453.870.500
Unique ID: D042926
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D042926
Annotation: /antag: coordinate with CYTOCHROME P-450 ENZYME INHIBITORS
Scope Note: A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as OCTANES and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.
Entry Term(s): Alkane 1-Hydroxylase; Alkane 1-Monooxygenase; Alkane Hydroxylase; CYP4A; Cytochrome P-450 4A; Cytochrome P-450 IVA; Fatty Acid Omega-Hydroxylase; Laurate Omega-Hydroxylase; Lauric Acid (Omega-1)-Hydroxylase; Lauric Acid Hydroxylase; Lauric Acid Monooxygenase; Lauric Acid Omega-hydroxylase; Omega-1 Hydroxylase; Omega-Hydroxylase; Omega-Lauryl Hydroxylase
Registry Numbers: EC 1.14.15.3
Related Numbers: 9059-16-9
Previous Indexing: Cytochrome P-450 Enzyme System (1982-2003); Lauric Acids (1979-1981); Mixed Function Oxygenases (1982-2003)
Public MeSH Note: 2004; see ALKANE 1-MONOXYGENASE 2004-2014; LAURIC ACID HYDROLASE (now ALKANE 1-MONOXYGENASE) was indexed under CYTOCHROME P-450 ENZYME SYSTEM & MIXED FUNCTION OXYGENASES 1982-2003, under LAURIC ACIDS 1979-1981
History Note: 2004(2015)
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 4 [D08.244.453.870]
      - Cytochrome P-450 CYP4A [D08.244.453.870.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 4 [D08.811.682.690.708.170.496]
        
        Cytochrome P-450 CYP4A [D08.811.682.690.708.170.496.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 4 [D12.776.422.220.453.870]
        
        Cytochrome P-450 CYP4A [D12.776.422.220.453.870.500]

Cytochrome P-450 CYP4A Preferred

Concept UI: M0076535
Registry Numbers: EC 1.14.15.3
Related Numbers: 9059-16-9
Scope Note: A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as OCTANES and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.
Terms: Cytochrome P-450 CYP4A Preferred Term
Term UI T520020
Date09/19/2002
LexicalTag ABX
ThesaurusID NLM (2004); Alkane Hydroxylase
Term UI T102323
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Fatty Acid Omega-Hydroxylase
Term UI T102328
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Omega-Hydroxylase
Term UI T102329
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Alkane 1-Monooxygenase
Term UI T102330
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); CYP4A
Term UI T106518
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Cytochrome P-450 4A
Term UI T106522
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); Cytochrome P-450 IVA
Term UI T106525
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2004); Alkane 1-Hydroxylase
Term UI T102322
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Lauric Acid (Omega-1)-Hydroxylase
Term UI T106533
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Lauric Acid Hydroxylase
Term UI T106534
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Lauric Acid Omega-hydroxylase
Term UI T106535
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Omega-1 Hydroxylase
Term UI T106536
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Omega-Lauryl Hydroxylase
Term UI T106537
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Lauric Acid Monooxygenase
Term UI T106538
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Laurate Omega-Hydroxylase
Term UI T106532
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004)

Cytochrome P-450 CYP4A MeSH Descriptor Data 2024