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Apolipoprotein E2 MeSH Descriptor Data 2022


MeSH Heading
Apolipoprotein E2
Tree Number(s)
D10.532.091.500.249
D12.776.070.400.500.249
D12.776.521.120.500.249
Unique ID
D053329
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053329
Scope Note
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Entry Term(s)
APOE-epsilon 2
APOE-epsilon2
Apo E-2
Apo E2
ApoE2
Apolipoprotein E-2
Apolipoprotein E-epsilon2
Registry Number
0
Previous Indexing
Apolipoproteins E (1984-2006)
Public MeSH Note
2007; APOLIPOPROTEIN E-2 was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPOPROTEINS 1984
History Note
2007 (1984)
Date Established
2007/01/01
Date of Entry
2006/07/05
Apolipoprotein E2 Preferred
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