MeSH Browser

MeSH Heading: Apolipoproteins E
Tree Number(s): D10.532.091.500; D12.776.070.400.500; D12.776.521.120.500
Unique ID: D001057
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001057
Scope Note: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Entry Term(s): Apo E; Apo E Isoproteins; Apo-E; ApoE; Apolipoprotein E Isoproteins; Apoprotein (E); Apoproteins E
Previous Indexing: Apolipoproteins (1977-1984)
Public MeSH Note: 1985; APOLIPOPROTEIN E ISOPROTEINS was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPOPROTEINS 1983-1984
History Note: 1985; for APOLIPOPROTEIN E ISOPROTEINS use APOLIPOPROTEINS E 1985-2006 & use APOLIPOPROTEINS 1983-1984
Date Established: 1985/01/01
Date of Entry: 1984/05/25
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0001601
Scope Note: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Terms: Apolipoproteins E Preferred Term
Term UI T003219
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1985); Apo E
Term UI T003220
Date05/25/1984
LexicalTag ABB
ThesaurusID UNK (19XX); Apo-E
Term UI T003221
Date05/25/1984
LexicalTag ABB
ThesaurusID UNK (19XX); ApoE
Term UI T003222
Date05/25/1984
LexicalTag ABB
ThesaurusID UNK (19XX)

Apolipoproteins E MeSH Descriptor Data 2025