MeSH Browser

MeSH Heading: Apolipoprotein E4
Tree Number(s): D10.532.091.500.750; D12.776.070.400.500.750; D12.776.521.120.500.750
Unique ID: D053327
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053327
Scope Note: A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Entry Term(s): Apo E epsilon 4; Apo E-4; Apo E4; ApoE4; Apolipoprotein E-4
Registry Numbers: 0
Previous Indexing: Apolipoproteins E (1982-2006)
Public MeSH Note: 2007; APOLIPOPROTEIN E-4 was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPPROTEINS 1982-1984
History Note: 2007 (1982)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0108562
Registry Numbers: 0
Scope Note: A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Terms: Apolipoprotein E4 Preferred Term
Term UI T138565
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apo E epsilon 4
Term UI T138561
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apo E-4
Term UI T138562
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apo E4
Term UI T138563
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); ApoE4
Term UI T138564
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Apolipoprotein E-4
Term UI T138566
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007)

Apolipoprotein E4 MeSH Descriptor Data 2024