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Apolipoprotein E4 MeSH Descriptor Data 2022


MeSH Heading
Apolipoprotein E4
Tree Number(s)
D10.532.091.500.750
D12.776.070.400.500.750
D12.776.521.120.500.750
Unique ID
D053327
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053327
Scope Note
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Entry Term(s)
Apo E epsilon 4
Apo E-4
Apo E4
ApoE4
Apolipoprotein E-4
Registry Number
0
Previous Indexing
Apolipoproteins E (1982-2006)
Public MeSH Note
2007; APOLIPOPROTEIN E-4 was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPPROTEINS 1982-1984
History Note
2007 (1982)
Date Established
2007/01/01
Date of Entry
2006/07/05
Apolipoprotein E4 Preferred
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