MeSH Browser

MeSH Heading: Pre-B Cell Receptors
Tree Number(s): D12.776.124.790.651.950.750; D12.776.377.715.548.950.750; D12.776.543.750.705.816.821.750
Unique ID: D054420
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054420
Scope Note: Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.
Entry Term(s): Pre-B Cell Receptor
Previous Indexing: Receptors, Antigen, B-Cell (1995-2007)
Public MeSH Note: 2008
History Note: 2008
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2017/06/30

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Pre-B Cell Receptors MeSH Descriptor Data 2025