Dual Specificity Phosphatase 2 MeSH Descriptor Data 2025

MeSH Heading: Dual Specificity Phosphatase 2
Tree Number(s): D08.811.277.352.650.587.250; D08.811.277.352.650.625.225.250; D08.811.277.352.650.775.250.250; D08.811.641.755.250; D12.776.476.445.250; D12.776.476.559.225.250; D12.776.476.564.250.250
Unique ID: D054641
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054641
Scope Note: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CELL NUCLEUS.
Entry Term(s): PAC-1 Phosphatase; PAC1 Phosphatase
Related Numbers: EC 3.1.3.18
Public MeSH Note: 2008; DUAL SPECIFICITY PHOSPHATASE 2 was indexed under PROTEIN TYROSINE PHOSPHATASES 1994-2007
History Note: 2008(1994)
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Mitogen-Activated Protein Kinase Phosphatases [D08.811.277.352.650.587]
        
        Dual Specificity Phosphatase 1 [D08.811.277.352.650.587.200]
        
        Dual Specificity Phosphatase 2 [D08.811.277.352.650.587.250]
        
        Dual Specificity Phosphatase 3 [D08.811.277.352.650.587.300]
        
        Dual Specificity Phosphatase 6 [D08.811.277.352.650.587.600]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Phosphoprotein Phosphatases [D08.811.277.352.650.625]
        
        Dual-Specificity Phosphatases [D08.811.277.352.650.625.225]
        
        cdc25 Phosphatases [D08.811.277.352.650.625.225.100]
        
        Dual Specificity Phosphatase 1 [D08.811.277.352.650.625.225.200]
        
        Dual Specificity Phosphatase 2 [D08.811.277.352.650.625.225.250]
        
        Dual Specificity Phosphatase 3 [D08.811.277.352.650.625.225.300]
        
        Dual Specificity Phosphatase 6 [D08.811.277.352.650.625.225.600]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
        
        Dual-Specificity Phosphatases [D08.811.277.352.650.775.250]
        
        cdc25 Phosphatases [D08.811.277.352.650.775.250.100]
        
        Dual Specificity Phosphatase 1 [D08.811.277.352.650.775.250.200]
        
        Dual Specificity Phosphatase 2 [D08.811.277.352.650.775.250.250]
        
        Dual Specificity Phosphatase 3 [D08.811.277.352.650.775.250.300]
        
        Dual Specificity Phosphatase 6 [D08.811.277.352.650.775.250.600]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Multifunctional Enzymes [D08.811.641]
    - Dual-Specificity Phosphatases [D08.811.641.755]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Mitogen-Activated Protein Kinase Phosphatases [D12.776.476.445]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Phosphoprotein Phosphatases [D12.776.476.559]
      - Dual-Specificity Phosphatases [D12.776.476.559.225]
        
        cdc25 Phosphatases [D12.776.476.559.225.100]
        
        Dual Specificity Phosphatase 1 [D12.776.476.559.225.200]
        
        Dual Specificity Phosphatase 2 [D12.776.476.559.225.250]
        
        Dual Specificity Phosphatase 3 [D12.776.476.559.225.300]
        
        Dual Specificity Phosphatase 6 [D12.776.476.559.225.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Tyrosine Phosphatases [D12.776.476.564]
      - Dual-Specificity Phosphatases [D12.776.476.564.250]
        
        cdc25 Phosphatases [D12.776.476.564.250.100]
        
        Dual Specificity Phosphatase 1 [D12.776.476.564.250.200]
        
        Dual Specificity Phosphatase 2 [D12.776.476.564.250.250]
        
        Dual Specificity Phosphatase 3 [D12.776.476.564.250.300]
        
        Dual Specificity Phosphatase 6 [D12.776.476.564.250.600]

Dual Specificity Phosphatase 2 Preferred

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