MeSH Browser

MeSH Heading: Nuclear Receptor Co-Repressor 2
Tree Number(s): D12.776.930.780.625.400
Unique ID: D056985
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056985
Scope Note: A nuclear co-repressor protein that shows specificity for RETINOIC ACID RECEPTORS and THYROID HORMONE RECEPTORS. The dissociation of this co-repressor from nuclear receptors is generally ligand-dependent, but can also occur by way of its phosphorylation by members of the MAP KINASE SIGNALING SYSTEM. The protein contains two nuclear receptor interaction domains and four repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 1.
Entry Term(s): SMRT Co-repressor; Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor; T3 Receptor-associating Factor; TRAC Co-repressor
Public MeSH Note: 2010; NUCLEAR RECEPTOR CO-REPRESSOR 2 was indexed under DNA-BINDING PROTEINS and REPRESSOR PROTEINS 1995-2009
History Note: 2010(1995)
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2015/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Nuclear Receptor Co-Repressor 2 MeSH Descriptor Data 2025