MeSH Browser

MeSH Heading: Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
Tree Number(s): D08.811.464.938.750.092.750; D12.776.167.024.750
Unique ID: D064190
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064190
Scope Note: Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.
Entry Term(s): Anapc2; Apc2 Subunit, Anaphase-Promoting Complex
Registry Numbers: EC 2.3.2.27
Previous Indexing: Cell Cycle Proteins (1996-2003); Ligases (1996-2003); Ubiquitin-Protein Ligase Complexes (2003-2013)
Public MeSH Note: 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2016/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0580157
Registry Numbers: EC 2.3.2.27
Scope Note: Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.
Terms: Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome Preferred Term
Term UI T836573
Date01/31/2013
LexicalTag ACX
ThesaurusID NLM (2014); Anapc2
Term UI T835299
Date01/08/2013
LexicalTag ABB
ThesaurusID NLM (2014); Apc2 Subunit, Anaphase-Promoting Complex
Term UI T835335
Date01/09/2013
LexicalTag ACX
ThesaurusID NLM (2014)

Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome MeSH Descriptor Data 2024