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Enhancer of Zeste Homolog 2 Protein MeSH Descriptor Data 2023


MeSH Heading
Enhancer of Zeste Homolog 2 Protein
Tree Number(s)
D05.500.781.750.250
D08.811.913.555.500.800.200.500.500.500
D12.776.660.235.600.200.250
D12.776.664.235.800.200.250
D12.776.930.780.890.200.250
Unique ID
D000071221
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071221
Scope Note
A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.
Entry Term(s)
Enhancer of Zeste Homolog 2
Histone-Lysine N-Methyltransferase EZH2
Lysine N-Methyltransferase-6
Registry Number
EC 2.1.1.43
Public MeSH Note
2017; ENHANCER OF ZESTE HOMOLOG 2 was indexed under POLYCOMB REPRESSIVE COMPLEX 2 2013-2016, under DNA-BINDING PROTEINS and TRANSCRIPTION FACTORS 2005-2012, and under PROTEINS 2005
History Note
2017 (2005)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2018/06/19
Enhancer of Zeste Homolog 2 Protein Preferred
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