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Protein Kinase C-theta MeSH Descriptor Data 2023


MeSH Heading
Protein Kinase C-theta
Tree Number(s)
D08.811.913.696.620.682.700.725.075
D12.776.476.563.725.075
Unique ID
D000074121
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074121
Scope Note
A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
Entry Term(s)
PKC-theta
PRKCQ
Protein Kinase C theta
Protein Kinase C, theta
Registry Number
EC 2.7.11.13
Previous Indexing
Isoenzymes (1992-2017)
Protein Kinase C (1992-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/05/21
Protein Kinase C-theta Preferred
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