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Eplerenone
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Eplerenone
Tree Number(s)
D02.540.383
D04.210.500.745.745.329
Unique ID
D000077545
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077545
Scope Note
A spironolactone derivative and selective
ALDOSTERONE RECEPTOR
antagonist that is used in the management of
HYPERTENSION
and
CONGESTIVE HEART FAILURE
, post-MYOCARDIAL
INFARCTION
.
Entry Term(s)
9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone
Eplerenon
Inspra
Pharm Action
Mineralocorticoid Receptor Antagonists
Antihypertensive Agents
CAS Type 1 Name
Spiro(cyclopenta(7,8)phenanthro(4b,5-b)oxirene-7(3H),2'(3'H)-furan)-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7 R,9aS,9bR,10R)-
Public MeSH Note
2019; EPLERENONE was indexed under SPIRONOLACTONE/analogs&derivatives 2000-2018
History Note
2019 (2000)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/04/09
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analogs & derivatives (AA)
analysis (AN)
antagonists & inhibitors (AI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
economics (EC)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
urine (UR)
Organic Chemicals [D02]
Lactones [D02.540]
4-Butyrolactone [D02.540.150]
Acyl-Butyrolactones [D02.540.232]
Dehydroascorbic Acid [D02.540.260]
Eplerenone [D02.540.383]
Macrolides [D02.540.505]
Orlistat [D02.540.529]
Picrotoxin [D02.540.552]
Polyketides [D02.540.576]
Propiolactone [D02.540.600]
Spironolactone [D02.540.679]
Venturicidins [D02.540.800]
Zearalenone [D02.540.950]
Polycyclic Compounds [D04]
Fused-Ring Compounds [D04.210]
Steroids [D04.210.500]
Pregnanes [D04.210.500.745]
Pregnenes [D04.210.500.745.745]
Cortisone [D04.210.500.745.745.183]
Dimethisterone [D04.210.500.745.745.279]
Eplerenone [D04.210.500.745.745.329]
Ethisterone [D04.210.500.745.745.379]
Pregnenediones [D04.210.500.745.745.654]
Pregnenolone [D04.210.500.745.745.725]
Spironolactone [D04.210.500.745.745.855]
Expand All
Collapse All
Eplerenone
Preferred
Concept UI
M0371594
Scope Note
A spironolactone derivative and selective
ALDOSTERONE RECEPTOR
antagonist that is used in the management of
HYPERTENSION
and
CONGESTIVE HEART FAILURE
, post-MYOCARDIAL
INFARCTION
.
Terms
Eplerenone
Preferred Term
Term UI
T000940099
Date
02/06/2018
LexicalTag
NON
ThesaurusID
Eplerenon
Term UI
T000940100
Date
02/06/2018
LexicalTag
NON
ThesaurusID
NLM (2009)
Inspra
Narrower
Concept UI
M0439953
Terms
Inspra
Preferred Term
Term UI
T522479
Date
10/15/2002
LexicalTag
TRD
ThesaurusID
US
9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone
Related
Concept UI
M000640866
Terms
9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone
Preferred Term
Term UI
T000940102
Date
02/06/2018
LexicalTag
NON
ThesaurusID
NLM (2010)
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