MeSH Browser

MeSH Heading: Eplerenone
Tree Number(s): D02.540.383; D04.210.500.745.745.329
Unique ID: D000077545
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077545
Scope Note: A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.
Entry Term(s): 9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone; Eplerenon; Inspra
Pharm Action: Mineralocorticoid Receptor Antagonists
Antihypertensive Agents
CAS Type 1 Name: Spiro(cyclopenta(7,8)phenanthro(4b,5-b)oxirene-7(3H),2'(3'H)-furan)-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7 R,9aS,9bR,10R)-
Public MeSH Note: 2019; EPLERENONE was indexed under SPIRONOLACTONE/analogs&derivatives 2000-2018
History Note: 2019 (2000)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Eplerenone MeSH Descriptor Data 2025