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Picrotoxin MeSH Descriptor Data 2021


MeSH Heading
Picrotoxin
Tree Number(s)
D02.455.426.392.368.367.800
D02.540.552
Unique ID
D010852
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D010852
Scope Note
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Pharm Action
Central Nervous System Stimulants
Antidotes
Convulsants
GABA Antagonists
Registry Number
124-87-8
CAS Type 1 Name
3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1)
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2006/07/05
Picrotoxin Preferred
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