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Picrotoxin MeSH Descriptor Data 2024


MeSH Heading
Picrotoxin
Tree Number(s)
D02.455.426.392.368.367.800
D02.455.849.765.636
D02.540.552
D20.215.784.500.647
D23.946.649
D26.667.750
Unique ID
D010852
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D010852
Scope Note
A mixture of PICROTOXININ and PICROTIN that is a noncompetitive antagonist at GABA-A receptors acting as a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Entry Term(s)
3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8
Cocculin
Pharm Action
Central Nervous System Stimulants
Antidotes
Convulsants
GABA-A Receptor Antagonists
Registry Numbers
ZLT174DL7U
Related Numbers
124-87-8
Public MeSH Note
1966
History Note
1966
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2022/04/08
Picrotoxin Preferred
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