MeSH Browser

MeSH Heading: Ketamine
Tree Number(s): D02.455.426.392.368.367.652
Unique ID: D007649
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007649
Scope Note: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
Entry Term(s): 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; CI-581; Calipsol; Calypsol; Kalipsol; Ketalar; Ketamine Hydrochloride; Ketanest; Ketaset
Pharm Action: Analgesics
Anesthetics, Dissociative
Excitatory Amino Acid Antagonists
Related Numbers: 1867-66-9; 6740-88-1; O18YUO0I83
CAS Type 1 Name: Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)-
NLM Classification #: QV 81
Previous Indexing: Analgesics (1966-1971); Anesthetics (1972); Cyclohexanes (1968-1972)
Public MeSH Note: 73
Online Note: use KETAMINE to search CI-581 1969-72 (as Prov)
History Note: 73; was CI-581 1969-72 (Prov)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Ketamine MeSH Descriptor Data 2025