MeSH Browser

MeSH Heading: Orlistat
Tree Number(s): D02.540.529
Unique ID: D000077403
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077403
Scope Note: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.
Entry Term(s): 1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate; Alli; Ro-18-0647; THLP; Tetrahydrolipastatin; Tetrahydrolipstatin; Xenical
Pharm Action: Enzyme Inhibitors
Anti-Obesity Agents
Lipid Regulating Agents
Related Numbers: 96829-58-2
CAS Type 1 Name: L-Leucine, N-formyl-, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester, (2S-(2alpha(R*),3beta))-
Public MeSH Note: 2019; ORLISTAT was indexed under LACTONES 1988-2018
History Note: 2019 (1988)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0155332
Related Numbers: 96829-58-2
Scope Note: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.
Terms: Orlistat Preferred Term
Term UI T000939569
Date01/24/2018
LexicalTag NON
ThesaurusID; Tetrahydrolipastatin
Term UI T000939571
Date01/24/2018
LexicalTag NON
ThesaurusID NLM (2011); Tetrahydrolipstatin
Term UI T000939572
Date01/24/2018
LexicalTag NON
ThesaurusID NLM (1988); THLP
Term UI T185335
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (1988)

Orlistat MeSH Descriptor Data 2025