MeSH Browser

MeSH Heading: Cilastatin, Imipenem Drug Combination
Tree Number(s): D02.065.589.099.124.300.500.500; D02.455.426.392.368.533.200.500; D03.633.100.300.124.300.500.500; D10.251.355.325.200.500; D26.310.356
Unique ID: D000077728
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077728
Scope Note: Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent.
Entry Term(s): Imipenem - Cilastatin; Imipenem - Cilastatin Sodium; Imipenem Cilastatin; Imipenem Cilastatin Sodium; Imipenem-Cilastatin; Imipenem-Cilastatin Sodium; Imipenem-Cilastatin, Sodium Salt; MK 0787-MK 0791 mixture; MK 787-MK 791 mixture; Primaxin; Thienam; Tienam 500; Zienam
Pharm Action: Anti-Bacterial Agents
Protease Inhibitors
Related Numbers: 85960-17-4
Public MeSH Note: 2019; CILASTATIN, IMIPENEM DRUG COMBINATION was indexed under CILASTATIN and IMIPENEM 1995-2018 and 1988-1994; under DRUG COMBINATIONS 1995-2018 and 1985-1994; and under CYCLOPROPANES and THIENAMYCINS 1985-1988
History Note: 2019 (1985)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0130282
Related Numbers: 85960-17-4
Scope Note: Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent.
Terms: Cilastatin, Imipenem Drug Combination Preferred Term
Term UI T000940940
Date03/08/2018
LexicalTag NON
ThesaurusID NLM (2009); Imipenem - Cilastatin
Term UI T000940941
Date03/08/2018
LexicalTag NON
ThesaurusID NLM (2010); Imipenem-Cilastatin
Term UI T000940942
Date03/08/2018
LexicalTag NON
ThesaurusID NLM (1985); Imipenem Cilastatin
Term UI T000941292
Date03/20/2018
LexicalTag NON
ThesaurusID NLM (2019)

Concept UI: M0322079
Terms: Imipenem-Cilastatin, Sodium Salt Preferred Term
Term UI T000940943
Date03/08/2018
LexicalTag NON
ThesaurusID NLM (1985); Imipenem-Cilastatin Sodium
Term UI T000940944
Date03/08/2018
LexicalTag NON
ThesaurusID NLM (2019); Imipenem Cilastatin Sodium
Term UI T000941293
Date03/20/2018
LexicalTag NON
ThesaurusID NLM (2019); Imipenem - Cilastatin Sodium
Term UI T000940945
Date03/08/2018
LexicalTag NON
ThesaurusID NLM (2019)

Cilastatin, Imipenem Drug Combination MeSH Descriptor Data 2025