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Cilastatin MeSH Descriptor Data 2023


MeSH Heading
Cilastatin
Tree Number(s)
D02.455.426.392.368.533.200
D10.251.355.325.200
Unique ID
D015377
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015377
Scope Note
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Entry Term(s)
Cilastatin Monosodium Salt
Cilastatin Sodium
MK 0791
MK-791
MK0791
Pharm Action
Protease Inhibitors
Registry Number
141A6AMN38
Related Numbers
5428WXZ74M
81129-83-1
82009-34-5
CAS Type 1 Name
2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-
Previous Indexing
Cyclopropanes (1983-1988)
Dipeptidases/antagonists & inhibitors (1983-1988)
Protease Inhibitors (1983-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/06/03
Revision Date
2016/06/28
Cilastatin Preferred
MK 0791 Narrower
Cilastatin Sodium Narrower
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