MeSH Browser

MeSH Heading: Protein-Arginine Deiminase Type 1
Tree Number(s): D08.811.277.721.250
Unique ID: D000080062
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000080062
Scope Note: A peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.
Entry Term(s): PAD Type I; PADI1 Protein; Peptidyl Arginine Deiminase Type 1; Peptidyl Arginine Deiminase Type I; Peptidylarginine Deiminase I; Peptidylarginine Deiminase Type 1; Peptidylarginine Deiminase Type I; Protein Arginine Deiminase 1; Protein Arginine Deiminase Type 1; Protein Arginine Deiminase Type I; Protein-Arginine Deiminase Type I
Registry Number: EC 3.5.3.15
See Also: Citrullination
Public MeSH Note: 2020; for PEPTIDYLARGININE DEIMINASE TYPE I see HYDROLASES (1999-2019)
History Note: 2020 (1999)
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/05/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Protein-Arginine Deiminases [D08.811.277.721]

Protein-Arginine Deiminase Type 1 Preferred

Concept UI: M000646299
Registry Number: EC 3.5.3.15
Scope Note: A peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.
Terms: Protein-Arginine Deiminase Type 1 Preferred Term
Term UI T000949969
Date12/21/2018
LexicalTag NON
ThesaurusID NLM (2020); Peptidyl Arginine Deiminase Type I
Term UI T000950220
Date01/02/2019
LexicalTag NON
ThesaurusID NLM (2020); Protein Arginine Deiminase Type 1
Term UI T000950221
Date01/02/2019
LexicalTag NON
ThesaurusID NLM (2020); Protein Arginine Deiminase Type I
Term UI T000950222
Date01/02/2019
LexicalTag NON
ThesaurusID NLM (2020); PAD Type I
Term UI T000949798
Date12/17/2018
LexicalTag NON
ThesaurusID NLM (2020); Peptidylarginine Deiminase I
Term UI T000949983
Date12/21/2018
LexicalTag NON
ThesaurusID NLM (2020); Protein Arginine Deiminase 1
Term UI T000949984
Date12/21/2018
LexicalTag NON
ThesaurusID NLM (2020); Peptidylarginine Deiminase Type 1
Term UI T000949796
Date12/17/2018
LexicalTag NON
ThesaurusID NLM (2020); PADI1 Protein
Term UI T000949815
Date12/17/2018
LexicalTag NON
ThesaurusID NLM (2020); Peptidylarginine Deiminase Type I
Term UI T000949797
Date12/17/2018
LexicalTag NON
ThesaurusID NLM (2020); Peptidyl Arginine Deiminase Type 1
Term UI T000950219
Date01/02/2019
LexicalTag NON
ThesaurusID NLM (2020); Protein-Arginine Deiminase Type I
Term UI T000949980
Date12/21/2018
LexicalTag NON
ThesaurusID NLM (2020)

Protein-Arginine Deiminase Type 1 MeSH Descriptor Data 2023