MeSH Browser

MeSH Heading: Endothelial PAS Domain-Containing Protein 1
Tree Number(s): D12.776.260.103.594; D12.776.930.125.594
Unique ID: D000099162
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099162
Scope Note: A basic helix-loop-helix transcription factor that regulates expression of genes in response to oxygen, including VASCULAR ENDOTHELIAL GROWTH FACTOR. It plays a role in the development of blood vessels (NEOVASCULARIZATION, PHYSIOLOGIC) and lung tissue.
Entry Term(s): EPAS1 Protein; Endothelial PAS Protein-1; HIF-2 alpha; HIF-Related Factor; HIF2alpha Protein; HLF Protein (bHLH-PAS); HRF Transcription Factor; Hypoxia-Inducible Factor 2, alpha Subunit; Hypoxia-Inducible Factor 2a; bHLH-PAS Factor HLF
Public MeSH Note: 2026; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1 was indexed under BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS 2006-2025, and under TRANS-ACTIVATORS 1997-2005
History Note: 2026 (1997)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Basic Helix-Loop-Helix Proteins [D12.776.260.103]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Basic Helix-Loop-Helix Proteins [D12.776.930.125]

Endothelial PAS Domain-Containing Protein 1 Preferred

Concept UI: M000768836
Scope Note: A basic helix-loop-helix transcription factor that regulates expression of genes in response to oxygen, including VASCULAR ENDOTHELIAL GROWTH FACTOR. It plays a role in the development of blood vessels (NEOVASCULARIZATION, PHYSIOLOGIC) and lung tissue.
Terms: Endothelial PAS Domain-Containing Protein 1 Preferred Term
Term UI T001147490
Date03/18/2025
LexicalTag NON
ThesaurusID NLM (1997); bHLH-PAS Factor HLF
Term UI T001147491
Date03/18/2025
LexicalTag ABX
ThesaurusID NLM (1997); Endothelial PAS Protein-1
Term UI T001147492
Date03/18/2025
LexicalTag ABX
ThesaurusID NLM (1997); EPAS1 Protein
Term UI T001147493
Date03/18/2025
LexicalTag ABX
ThesaurusID NLM (1999); HIF-2 alpha
Term UI T424957
Date09/25/2000
LexicalTag ABB
ThesaurusID NLM (2000); HIF-Related Factor
Term UI T001147494
Date03/18/2025
LexicalTag ABX
ThesaurusID NLM (1997); HIF2alpha Protein
Term UI T001147495
Date03/18/2025
LexicalTag ABX
ThesaurusID NLM (2005); HLF Protein (bHLH-PAS)
Term UI T001147496
Date03/18/2025
LexicalTag ABX
ThesaurusID NLM (1997); HRF Transcription Factor
Term UI T001147497
Date03/18/2025
LexicalTag ABX
ThesaurusID NLM (1997); Hypoxia-Inducible Factor 2, alpha Subunit
Term UI T001147498
Date03/18/2025
LexicalTag NON
ThesaurusID NLM (2026); Hypoxia-Inducible Factor 2a
Term UI T001147499
Date03/18/2025
LexicalTag NON
ThesaurusID NLM (2026)

Endothelial PAS Domain-Containing Protein 1 MeSH Descriptor Data 2026